JNCI cancer spectrum · 2026
Comparing chemotherapy-induced nausea and vomiting between young adult vs non-young adult cancer patients.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод в очереди
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Oswald Laura B, Hoogland Aasha I, Welniak Taylor L, Nguyen Oanh L, Rodriguez Yvelise, Li Xiaoyin, Reese Samantha, Lake Paige W, Gonzalez Brian D, Extermann Martine, Metts Jonathan, Murphy Matthew A, Small Brent J, Berry Donna L, Li Daneng, Carpenter Kristen M, Fischer Stacy M, Kinney Anita Y, Jim Heather S L
Аннотация
Chemotherapy-induced nausea and vomiting are among the most distressing side effects of cancer therapy. Younger age is a risk factor for chemotherapy-induced nausea and vomiting, and cancer incidence is rising among young adults ages 18-39 years. However, the comparative burden of chemotherapy-induced nausea and vomiting in young adults vs non-young adults remains insufficiently understood. This study compared acute and delayed chemotherapy-induced nausea and vomiting between young adults and non-young adults (ie, ages 40 years and older) after the first infusion of moderately or highly emetogenic chemotherapy. Of 1609 participants, 159 (10%) were young adults. Rates of guideline-consistent antiemetic prophylactic care were similar between groups (65% young adults, 71% non-young adults; P = .11). Despite this, acute nausea was more prevalent (69% vs 40%; P < .001) and severe (mean [SD] = 3.9 [2.6] vs mean = 3.0 [2.3] on 0-10 scale; P < .001) among young adults vs non-young adults. Similarly, delayed nausea was more prevalent (85% vs 69%; P < .001) and severe (mean = 4.5 [2.4] vs mean = 3.7 [2.5]; P < .001) among young adults. Findings may inform clinical approaches to managing chemotherapy-induced nausea and vomiting among young adults.