The Journal of clinical endocrinology and metabolism · 2018
Subclinical Changes in Maternal Thyroid Function Parameters in Pregnancy and Fetal Growth.
СтатьяПоддержка NIH: внешняя программаResearch Support, N.I.H., IntramuralПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Johns Lauren E, Ferguson Kelly K, Cantonwine David E, Mukherjee Bhramar, Meeker John D, McElrath Thomas F
Аннотация
CONTEXT: Overt thyroid disease in pregnancy is a known risk factor for abnormal fetal growth and development. Data on the effects of milder forms of variation in maternal thyroid function on intrauterine growth are less well examined.
OBJECTIVE: We explored these associations using repeated thyroid hormone and ultrasound measurements.
DESIGN, SETTING, AND PARTICIPANTS: Data were obtained from 439 pregnant women without diagnosed thyroid disease who were participants in a case-control study of preterm birth nested within an ongoing prospective birth cohort in Boston, Massachusetts.
MAIN OUTCOME MEASURES: Ultrasound and delivery indices of fetal growth were standardized to those measured in a larger population.
RESULTS: At median 10, 18, and 26 weeks of gestation, we observed significant inverse associations between free thyroxine (FT4) and birth weight z scores, with the strongest association detected at median 10 weeks, at which time a 10% increase in FT4 was associated with a 0.02 z score decrease (∼8.5 g) in birth weight (β = -0.41 for ln-transformed FT4; 95% confidence interval, -0.64 to -0.18). FT4 was also inversely associated with repeated measurements of estimated fetal weight, head circumference, and abdominal circumference. We observed weaker inverse associations for total T4 and a positive relationship between total triiodothyronine and birth weight z scores. We did not observe any associations for thyroid-stimulating hormone.
CONCLUSION: In pregnant women without overt thyroid disease, subclinical changes in thyroid function parameters may influence fetal growth.
OBJECTIVE: We explored these associations using repeated thyroid hormone and ultrasound measurements.
DESIGN, SETTING, AND PARTICIPANTS: Data were obtained from 439 pregnant women without diagnosed thyroid disease who were participants in a case-control study of preterm birth nested within an ongoing prospective birth cohort in Boston, Massachusetts.
MAIN OUTCOME MEASURES: Ultrasound and delivery indices of fetal growth were standardized to those measured in a larger population.
RESULTS: At median 10, 18, and 26 weeks of gestation, we observed significant inverse associations between free thyroxine (FT4) and birth weight z scores, with the strongest association detected at median 10 weeks, at which time a 10% increase in FT4 was associated with a 0.02 z score decrease (∼8.5 g) in birth weight (β = -0.41 for ln-transformed FT4; 95% confidence interval, -0.64 to -0.18). FT4 was also inversely associated with repeated measurements of estimated fetal weight, head circumference, and abdominal circumference. We observed weaker inverse associations for total T4 and a positive relationship between total triiodothyronine and birth weight z scores. We did not observe any associations for thyroid-stimulating hormone.
CONCLUSION: In pregnant women without overt thyroid disease, subclinical changes in thyroid function parameters may influence fetal growth.
Предметные рубрики MeSH
AdolescentAdultAsymptomatic DiseasesBirth WeightCase-Control StudiesFemaleFetal DevelopmentHumansInfant, NewbornPregnancyPregnancy ComplicationsPremature BirthProspective StudiesSocioeconomic FactorsThyroid DiseasesThyroid Function TestsThyroid GlandThyroid HormonesThyroxineUltrasonography, PrenatalYoung Adult