Ascertainment of Cancer Cases in the German National Cohort (NAKO): Methods and Initial Results.
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Katzke Verena A, Arndt Volker, Greiser Karin Halina, Karpa Florian, Zoller Dorothee, Fortner Renée, Steindorf Karen, Hoffmeister Michael, Brenner Hermann, Schirmacher Peter, Leitzmann Michael, Nimptsch Katharina, Haug Ulrike, Hofmann Katharina, Stallmann Christoph, Mueller Ulrich, Werdecker Andrea, Pigeot Iris, Swart Enno, Ahrens Wolfang, Meyer Martin, Luttmann Sabine, Nennecke Alice, von Rüsten Anne, Kieschke Joachim, Hartz Tobias, Stang Andreas, Hoffmann Wolfgang, Holleczek Bernd, Fabian Hans Gert, Peters Annette, Willich Stefan N, Krist Lilian, Schulze Matthias B, Guenther Kathrin, Zeeb Hajo, Ebert Nina, Schmidt Börge, Köttgen Anna, Kluttig Alexander, Mikolajczyk Rafael, Harth Volker, Obi Nadia, Klett-Tammen Carolina, Harries Manuela, Lieb Wolfgang, Becher Heiko, Minnerup Heike, Karch André, Meinke-Franze Claudia, Baurecht Hansjörg, Mons Ute, Koch-Gallenkamp Lena, Berger Klaus, Völzke Henry, Pischon Tobias, Katalinic Alexander, Kaaks Rudolf
Аннотация
METHODS: We describe the methods of ascertaining cancer cases in NAKO (linkage with cancer registries and self-reporting), the incidence and prevalence figures obtained so far, and the ratio of observed to expected (O/E) case numbers.
RESULTS: Altogether, 2774 prevalent (diagnosed within the 5 years prior to study enrollment) and 4295 incident (diagnosed up to 5 years after enrollment) cancer cases were identified. Breast, prostate, lung, and colorectal cancers made up 55% of the incident cases. Fewer incident cases were found than would have been expected on the basis of incidence rates in the general population (O/E ratio 0.80, 95% confidence interval [0.76;0.83] for the first 2 years of prospective follow-up). The O/E ratio varied, however, across tumor sites (breast 1.02, prostate 1.12, lung 0.38, colorectal 0.62). Possible explanations include bias caused by the fact that most study participants were healthy, delayed tumor reporting, incomplete data linkage, and incomplete self-reporting.
CONCLUSION: Rising case numbers for the most commonly occurring types of cancer are expected in the next few years. This will enable comprehensive epidemiological analysis of the risk factors for cancer.