Journal of pediatric and adolescent gynecology · 2014
A randomized crossover study of medroxyprogesterone acetate and Diane-35 in adolescent girls with polycystic ovarian syndrome.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Chung Jacqueline P W, Yiu Alice K W, Chung Tony K H, Chan Symphorosa S C
Аннотация
OBJECTIVE: To investigate the effects of 4-month treatment of medroxyprogesterone acetate (MPA) and Diane-35 on the clinical and biochemical features of hyperandrogenism and quality of life of adolescent girls with polycystic ovarian syndrome (PCOS).
DESIGN: A prospective, randomized, cross-over study.
SETTING: An accredited pediatric and adolescent gynecology clinic of a university-affiliated tertiary hospital.
PARTICIPANTS: 76 adolescents girls aged 14 to 19 years old with PCOS were recruited from July 2007 to July 2010.
INTERVENTIONS: Girls were randomized into 2 groups. Group 1 received oral MPA for 4 months, followed by a washout period of 4 months, and then Diane-35 for another 4 months. Group 2 received the same combination but in the reverse order.
MAIN OUTCOME MEASURES: Clinical and biochemical features of hyperandrogenism and quality of life were assessed.
RESULTS: There was no significant difference between the 2 groups at baseline. No significant difference was found in the clinical and biochemical parameters of hyperandrogenism before and after treatment with MPA. Significant reduction of the acne score, LH/FSH ratio, and testosterone level was seen after taking Diane-35. Hirsutism was also improved but it did not reach statistical significant. When comparing post-MPA and post-Diane-35, the post-Diane-35 group had significantly improved acne score and LH/FSH ratio. No significant difference was found on quality of life between both groups after treatment.
CONCLUSION: Diane-35 may be a more suitable treatment option in adolescent girls diagnosed with PCOS when compared to MPA.
DESIGN: A prospective, randomized, cross-over study.
SETTING: An accredited pediatric and adolescent gynecology clinic of a university-affiliated tertiary hospital.
PARTICIPANTS: 76 adolescents girls aged 14 to 19 years old with PCOS were recruited from July 2007 to July 2010.
INTERVENTIONS: Girls were randomized into 2 groups. Group 1 received oral MPA for 4 months, followed by a washout period of 4 months, and then Diane-35 for another 4 months. Group 2 received the same combination but in the reverse order.
MAIN OUTCOME MEASURES: Clinical and biochemical features of hyperandrogenism and quality of life were assessed.
RESULTS: There was no significant difference between the 2 groups at baseline. No significant difference was found in the clinical and biochemical parameters of hyperandrogenism before and after treatment with MPA. Significant reduction of the acne score, LH/FSH ratio, and testosterone level was seen after taking Diane-35. Hirsutism was also improved but it did not reach statistical significant. When comparing post-MPA and post-Diane-35, the post-Diane-35 group had significantly improved acne score and LH/FSH ratio. No significant difference was found on quality of life between both groups after treatment.
CONCLUSION: Diane-35 may be a more suitable treatment option in adolescent girls diagnosed with PCOS when compared to MPA.
Предметные рубрики MeSH
Acne VulgarisAdolescentAndrogen AntagonistsCross-Over StudiesCyproterone AcetateDrug CombinationsEthinyl EstradiolFemaleFollicle Stimulating HormoneHirsutismHumansHyperandrogenismLuteinizing HormoneMedroxyprogesterone AcetatePolycystic Ovary SyndromeProspective StudiesQuality of LifeSeverity of Illness IndexTestosteroneYoung Adult