Wiadomosci lekarskie (Warsaw, Poland : 1960) · 2024
Diagnostic value of laboratory markers of enteric dysfunction in preterm infants.
СтатьяНазвание и аннотация: Перевод в очереди
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Godovanets Oleksii S
Аннотация
OBJECTIVE: Aim: To study the peculiarities of food tolerance disorders in premature infants, taking into account the risk factors of gestational age and maternal labor, the peculiarities of the course of perinatal pathology, in order to determine pathogenetically sound clinical and laboratory criteria.
PATIENTS AND METHODS: Materials and Methods: A comprehensive clinical and laboratory evaluation was performed on 67 preterm infants of gestational age 32 to 33/6 weeks with severe food tolerance disorders in perinatal pathology. The comparison group consisted of 31 newborns with gestational age of 34 to 37 weeks. In addition to standard laboratory tests, coprofiltrate parameters (albumin, alpha-1-antitrypsin, elastase, PMN elastase, calprotectin) were examined.
RESULTS: Results: The clinical signs of food intolerance included regurgitation and stasis (86,57%), intestinal paresis with delayed meconium and transitional stool (70,15%), flatulence (47,76%), bile or blood impurities in the stool (43,28%). The presence of pain syndromes in conjunction with eating dysfunction was accompanied by episodes of apnea, bradycardia, and decreased blood saturation. The laboratory markers of intestinal dysfunction were the following: increased levels of calprotectin > 390,15 μg/g; albumin > 37,25 μg/g; α-1-antitrypsin > 452,67 μg/g; decreased levels of PMN elastase <95,49 ng/g. The representativeness of these clinical and paraclinical parameters was investigated, which gave grounds to recommend their use in clinical practice in neonatology.
CONCLUSION: Conclusions: The implementation of recommendations for the use of laboratory markers of food intolerance, along with clinical signs, will increase the effectiveness of diagnostic measures in perinatal pathology in preterm infants.
PATIENTS AND METHODS: Materials and Methods: A comprehensive clinical and laboratory evaluation was performed on 67 preterm infants of gestational age 32 to 33/6 weeks with severe food tolerance disorders in perinatal pathology. The comparison group consisted of 31 newborns with gestational age of 34 to 37 weeks. In addition to standard laboratory tests, coprofiltrate parameters (albumin, alpha-1-antitrypsin, elastase, PMN elastase, calprotectin) were examined.
RESULTS: Results: The clinical signs of food intolerance included regurgitation and stasis (86,57%), intestinal paresis with delayed meconium and transitional stool (70,15%), flatulence (47,76%), bile or blood impurities in the stool (43,28%). The presence of pain syndromes in conjunction with eating dysfunction was accompanied by episodes of apnea, bradycardia, and decreased blood saturation. The laboratory markers of intestinal dysfunction were the following: increased levels of calprotectin > 390,15 μg/g; albumin > 37,25 μg/g; α-1-antitrypsin > 452,67 μg/g; decreased levels of PMN elastase <95,49 ng/g. The representativeness of these clinical and paraclinical parameters was investigated, which gave grounds to recommend their use in clinical practice in neonatology.
CONCLUSION: Conclusions: The implementation of recommendations for the use of laboratory markers of food intolerance, along with clinical signs, will increase the effectiveness of diagnostic measures in perinatal pathology in preterm infants.