The Epilepsy-Cog study: Methods to establish a harmonized study of late onset epilepsy in a metacohort of six population-based cohorts in the United States.
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Choi Hyunmi, Gutierrez Jose, Wang Tian, Liu Minghua, Leu Cheng-Shiun, Misiewicz Sylwia, Han Jiying, Bello Natalie, Biggs Mary L, Briceño Emily M, Brickman Adam M, Burke James F, Chen Ligong, Colantonio Lisandro D, Diaz Andino Stefany P, Elkind Mitchell S V, Fitzpatrick Annette L, Corona Christopher Gonzalez, Gottesman Rebecca F, Gross Alden L, Huang Lei, Johnson Emily L, Johnson W Craig, Levine Deborah A, Longstreth W T, Maia Sofia Pelagalli, Mayeux Richard P, Petersen Brian C, Obalana Oluwadamilola, Reyes-Dumeyer Dolly, Rundek Tatjana, Sanchez Danurys, Shea Steven J, Strobino Kevin, Zhu Carolyn W, Thacker Evan L
Аннотация
METHODS: The Epilepsy-Cog study includes individual participant data from six United States-based longitudinal cohort studies: Atherosclerosis Risk in Communities Study, Cardiovascular Health Study, Multi-Ethnic Study of Atherosclerosis, Northern Manhattan Study (NOMAS), Reasons for Geographic and Racial Differences in Stroke, and Washington Heights/Inwood Columbia Aging Project. In all cohorts except NOMAS, prevalent and incident epilepsy were ascertained using Medicare claims-based algorithms. In NOMAS, epilepsy cases were identified through cohort-based reporting and medical record review. To perform cross-cohort harmonization of variables, we used the lowest common denominator approach, assigning response categories or value levels in common across all cohorts.
RESULTS: From a total of 68 544 participants across six cohorts, 43 753 participants met eligibility criteria for Epilepsy-Cog. Among them, we identified 551 (1.3%) participants with prevalent epilepsy and 1500 (3.4%) participants with incident epilepsy. We have harmonized demographic characteristics, health behaviors, vascular risk factors (VRFs), one genetic variable, medication use, subjective health status measures, incident events, and cause-of-death variables.
SIGNIFICANCE: The Epilepsy-Cog pooled cohort of 43 753 participants with and without epilepsy, combined with harmonized demographic, VRF, and event data, offers a unique resource to yield new insights into LOE.