Journal of orthopaedic translation · 2026
Long-term evaluation of plasma electrolytic oxidation (PEO) surface-modified WE43MEO magnesium alloy screws and plates reveals safe and controlled degradation in a 18-month minipig model.
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Kopp Alexander, Schmitz Alina, Kreiker Henri, Fischer Heilwig, Soares Ana Prates, Schmidt-Bleek Katharina, Duda Georg, Hanken Henning, Kröger Nadja, Heiland Max, Smeets Ralf, Rendenbach Carsten
Аннотация
BACKGROUND: Magnesium-based implants are increasingly investigated as bioabsorbable materials for temporary osteosynthesis applications due to their favorable biocompatibility and bone-like elastic modulus. However, controlling the degradation rate remains a critical barrier to clinical translation, as rapid corrosion can compromise mechanical integrity and lead to adverse effects, such as gas formation.
METHODS: PEO-modified WE43MEO (WE43-PEO) and non-modified WE43MEO screws and plates were implanted in the humerus and femur of Göttinger minipigs in a non-fracture model and assessed after 18 months. Explants were analyzed using micro-computed tomography and non-decalcified histology with histomorphometric quantification of residual implant structure and peri-implant bone response.
RESULTS: No significant differences in cortical implant volume were observed. However, PEO modified implants were surrounded by significantly higher volumes of lamellar bone, suggesting reduced remodeling and improved bone integration. Non-modified WE43MEO implants underwent complete degradation, while PEO modified implants showed partial resorption with preserved structure, indicating effective degradation control. Both implant types remained integrated without long-term complications.
CONCLUSION: PEO surface modification of WE43 magnesium implants supports predictable, biocompatible long-term degradation and promotes favorable bone quality without late complications, underscoring the potential of surface-engineered magnesium fixation devices for load-bearing applications.
THE TRANSLATIONAL POTENTIAL OF THIS ARTICLE: PEO-modified WE43MEO osteosynthesis systems may offer clinically relevant, bioabsorbable fixation with controlled degradation and improved long-term bone integration, potentially reducing implant-related complications and the need for secondary removal procedures in orthopaedic and craniomaxillofacial surgery.
METHODS: PEO-modified WE43MEO (WE43-PEO) and non-modified WE43MEO screws and plates were implanted in the humerus and femur of Göttinger minipigs in a non-fracture model and assessed after 18 months. Explants were analyzed using micro-computed tomography and non-decalcified histology with histomorphometric quantification of residual implant structure and peri-implant bone response.
RESULTS: No significant differences in cortical implant volume were observed. However, PEO modified implants were surrounded by significantly higher volumes of lamellar bone, suggesting reduced remodeling and improved bone integration. Non-modified WE43MEO implants underwent complete degradation, while PEO modified implants showed partial resorption with preserved structure, indicating effective degradation control. Both implant types remained integrated without long-term complications.
CONCLUSION: PEO surface modification of WE43 magnesium implants supports predictable, biocompatible long-term degradation and promotes favorable bone quality without late complications, underscoring the potential of surface-engineered magnesium fixation devices for load-bearing applications.
THE TRANSLATIONAL POTENTIAL OF THIS ARTICLE: PEO-modified WE43MEO osteosynthesis systems may offer clinically relevant, bioabsorbable fixation with controlled degradation and improved long-term bone integration, potentially reducing implant-related complications and the need for secondary removal procedures in orthopaedic and craniomaxillofacial surgery.