Photodynamic therapy combined with circumcision for the treatment of penile intraepithelial neoplasia.

Penile intraepithelial neoplasia(PIN) is a premalignant lesion that can effect any part of the penile surface. Approximately 10-30 % of PIN patients are at risk of progression to squamous cell carcinoma (SCC), with metastatic potential of 3%-5% .. The use of photodynamic therapy (PDT) for PIN is currently controversial. Here, we performed circumcision in combination with PDT and successfully cured 3 cases of PIN. We considered that circumcision is very important before PDT. We recommend the treatment of circumcision combined with PDT to treat patients with PIN, especially for those who have failed previous treatment, or with an excessively long foreskin.