Cardiovascular & hematological agents in medicinal chemistry · 2024
Antihypertensive and ACE-2 Inhibitory Effects of Daphne gnidium in Rats.
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Bouadid Ismail, Qabouche Adil, Eddouks Mohamed
Аннотация
AIMS: The antihypertensive activity of Daphne gnidium was tested.
BACKGROUND: Daphne gnidium (Thymelaeaceae) is used against hypertension.
OBJECTIVE: The antihypertensive effect of Daphne gnidium was evaluated in this study.
METHODS: The effect of Daphne gnidium aqueous extract (DGAE, 100 and 180 mg/kg) on blood pressure was evaluated in rats. In addition, the vasorelaxant effect of this extract was also tested.
RESULTS: DGAE lowered blood pressure in hypertensive rats and exhibited vasorelaxant activity. In addition, cumulative concentrations of DGAE induced vasodilatation through receptoractivated calcium channels (ROCCs) without affecting ACE-2.
CONCLUSION: The aqueous extract of Daphne gnidium exhibits antihypertensive activity and induces vasodilatation via the inhibition of Ca2+ entry.
BACKGROUND: Daphne gnidium (Thymelaeaceae) is used against hypertension.
OBJECTIVE: The antihypertensive effect of Daphne gnidium was evaluated in this study.
METHODS: The effect of Daphne gnidium aqueous extract (DGAE, 100 and 180 mg/kg) on blood pressure was evaluated in rats. In addition, the vasorelaxant effect of this extract was also tested.
RESULTS: DGAE lowered blood pressure in hypertensive rats and exhibited vasorelaxant activity. In addition, cumulative concentrations of DGAE induced vasodilatation through receptoractivated calcium channels (ROCCs) without affecting ACE-2.
CONCLUSION: The aqueous extract of Daphne gnidium exhibits antihypertensive activity and induces vasodilatation via the inhibition of Ca2+ entry.