Fertility and sterility · 2014
Hyperandrogenemia is implicated in both the metabolic and reproductive morbidities of polycystic ovary syndrome.
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Sung Yeon-Ah, Oh Jee-Young, Chung Hyewon, Lee Hyejin
Аннотация
OBJECTIVE: To determine the features of polycystic ovary syndrome (PCOS) that are implicated in the associated reproductive and metabolic morbidities.
DESIGN: Cross-sectional case-control study.
SETTING: Academic medical setting.
PATIENT(S): A total of 1,062 women with PCOS and 1,887 women without PCOS.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Physical examination including hirsutism scoring, biochemical and hormone measurements, ovarian ultrasound, and a 75-g oral glucose tolerance test to measure glucose and insulin levels.
RESULT(S): A factor analysis identified four dominant factors in women with PCOS. These factors were interpreted as follows: [1] metabolic and hyperandrogenemia factor, [2] oligomenorrhea and hyperandrogenemia factor, [3] blood pressure factor, and [4] ovarian morphology factor. In women with PCOS, hyperandrogenemia was a significant predictor of metabolic syndrome after adjusting for age, body mass index, and insulin resistance in the regression analysis.
CONCLUSION(S): A factor analysis identified multiple factors that are responsible for the abnormalities associated with PCOS. Hyperandrogenemia was a common underlying feature of the metabolic and reproductive abnormalities in women with PCOS but not in women without PCOS.
DESIGN: Cross-sectional case-control study.
SETTING: Academic medical setting.
PATIENT(S): A total of 1,062 women with PCOS and 1,887 women without PCOS.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Physical examination including hirsutism scoring, biochemical and hormone measurements, ovarian ultrasound, and a 75-g oral glucose tolerance test to measure glucose and insulin levels.
RESULT(S): A factor analysis identified four dominant factors in women with PCOS. These factors were interpreted as follows: [1] metabolic and hyperandrogenemia factor, [2] oligomenorrhea and hyperandrogenemia factor, [3] blood pressure factor, and [4] ovarian morphology factor. In women with PCOS, hyperandrogenemia was a significant predictor of metabolic syndrome after adjusting for age, body mass index, and insulin resistance in the regression analysis.
CONCLUSION(S): A factor analysis identified multiple factors that are responsible for the abnormalities associated with PCOS. Hyperandrogenemia was a common underlying feature of the metabolic and reproductive abnormalities in women with PCOS but not in women without PCOS.