Research on the Mechanism of Iguratimod in Inhibiting Arthritis Through NF-κB: An Experimental Study Based on Network Pharmacology.

We investigated the mechanism by which Iguratimod (IGU) inhibits arthritis. IGU can inhibit inflammatory responses in synovial macrophages, reducing the levels of inflammatory factors and NF-κB signaling. In animal experiments, IGU can suppress mouse arthritis damage, decrease the levels of inflammatory factors in tissues, improve mouse mobility, and inhibit NF-κB signaling. IGU can target NF-κB signaling to inhibit inflammatory responses in synovial macrophages, thereby alleviating arthritis and joint damage, which is an important mechanism for IGU in the treatment of arthritis.