Acquired oral syphilis: A multicenter study of 339 patients from South America.
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de Andrade Bruno Augusto Benevenuto, de Arruda José Alcides Almeida, Gilligan Gerardo, Piemonte Eduardo, Panico René, Molina Ávila Ignacio, Pimentel Sola Juan Martin, Carmona Lorduy Martha Cecilia, Pupo Marrugo Stella, Sánchez Tatis Angélica Sofia, Werner Laura Cecilia, Abrahão Aline Corrêa, Agostini Michelle, Buoro Luisa, Israel Mônica Simões, Freire Nathália de Almeida, Lima Lucas Ambrósio, Abrantes Thamiris de Castro, Cunha John Lennon Silva, Pérez-de-Oliveira Maria Eduarda, Roza Ana Luiza Oliveira Corrêa, Vargas Pablo Agustin, Lopes Marcio Ajudarte, Santos-Silva Alan Roger, de Almeida Oslei Paes, Pontes Flávia Sirotheau Corrêa, Pontes Hélder Antônio Rebelo, Rondanelli Benjamin Martínez, Villarroel-Dorrego Mariana, Bologna-Molina Ronell, Derderian Nathalie, Sánchez-Romero Celeste, Abreu Lucas Guimarães, Fonseca Felipe Paiva, Mesquita Ricardo Alves, Gomez Ricardo Santiago, Martínez-Flores René, Delgado-Azañero Wilson, Alves Adriana Terezinha Neves Novellino, Lourenço Simone de Queiroz Chaves, Coimbra Carolina, Polignano Giovanni Augusto Castanheira, Assunção Júnior José Narciso Rosa, Souto Giovanna Ribeiro, Souza Paulo Eduardo Alencar, Horta Martinho Campolina Rebello, González-Arriagada Wilfredo Alejandro, Romañach Mário José
Аннотация
MATERIALS AND METHODS: Clinical data were retrospectively collected from the records of 18 oral diagnostic services in Argentina, Brazil, Chile, Colombia, Venezuela, Uruguay, and Peru. Serologies of nontreponemal and treponemal tests were used for diagnosis.
RESULTS: The series comprised 339 cases of acquired oral syphilis. Secondary syphilis ranked as the most common stage (86.7%). Lesions were more frequent among males (58.0%) and young adults with a mean age of 33.3 years. Individuals aged 20-29 years were most affected (35.3%). The most commonly involved sites were the tongue (31.6%), lip/labial commissure (25.1%), and hard/soft palate (20.4%). Clinically, acquired oral syphilis usually presented as mucous patches (28.4%), papules (25.7%), and ulcers (18.1%). Skin manifestations occurred in 67.7% of individuals, while lymphadenopathy and fever were observed in 61.3% and 11.6% of all subjects, respectively. Most patients were treated with the benzathine penicillin G antibiotic.
CONCLUSION: This report validates the spread of acquired oral syphilis infection among young adults in South America. Our directives include accessible diagnostic tools for proper disease screening, surveillance, and counselling of affected individuals, especially in low- and middle-income countries.