International journal of general medicine · 2025
Insulin Resistance as a Biomarker for Pelvic Organ Prolapse in Gestational Diabetes Mellitus: Stratification by Delivery Modes.
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Jiao Ying, Dai YongGang, He Lin, Fei Zhiyi
Аннотация
OBJECTIVE: This study was to observe the assessment value of insulin and insulin resistance level on pelvic organ prolapse (POP) in women with gestational diabetes mellitus (GDM) who experienced different delivery modes, and to analyze the association between insulin and insulin resistance level and pelvic organ prolapse in GDM.
METHODS: 150 GDM patients were selected as the observation group, with 150 healthy pregnant women as the control group. PG and HOMA-IR levels were compared between groups. Correlation analysis was conducted with Pearson method. Logistic regression was used to analyze the relationship between serum insulin and insulin resistance levels and POP in patients with GDM. The value of serum insulin and insulin resistance levels in predicting POP in patients with GDM was analyzed by ROC curves, and area under the curve (AUC) was compared by the Z test.
RESULTS: POP was detected in 148 out of 300 cases (49.3%), with a prevalence of 62.0% in the GDM group compared to 36.7% in the control group. PG and HOMA-IR levels were higher in GDM patients with POP. BMI ≥ 24 kg/m2, number of deliveries > 2, number of pregnancies > 2, gestational week ≥ 37 weeks, fetal weight ≥ 4 kg, mode of delivery, PG and HOMA-IR were risk factors for POP in patients with GDM. The AUC of PG for predicting POP in patients with GDM was 0.835 (95% CI: 0.702~0.845), and the AUC of HOMA-IR was 0.848 (95% CI: 0.768~0.922).
CONCLUSION: Insulin and insulin resistance levels are associated with POP in women with GDM with different modes of delivery, and their combined assessment may increase the predictive value for POP.
METHODS: 150 GDM patients were selected as the observation group, with 150 healthy pregnant women as the control group. PG and HOMA-IR levels were compared between groups. Correlation analysis was conducted with Pearson method. Logistic regression was used to analyze the relationship between serum insulin and insulin resistance levels and POP in patients with GDM. The value of serum insulin and insulin resistance levels in predicting POP in patients with GDM was analyzed by ROC curves, and area under the curve (AUC) was compared by the Z test.
RESULTS: POP was detected in 148 out of 300 cases (49.3%), with a prevalence of 62.0% in the GDM group compared to 36.7% in the control group. PG and HOMA-IR levels were higher in GDM patients with POP. BMI ≥ 24 kg/m2, number of deliveries > 2, number of pregnancies > 2, gestational week ≥ 37 weeks, fetal weight ≥ 4 kg, mode of delivery, PG and HOMA-IR were risk factors for POP in patients with GDM. The AUC of PG for predicting POP in patients with GDM was 0.835 (95% CI: 0.702~0.845), and the AUC of HOMA-IR was 0.848 (95% CI: 0.768~0.922).
CONCLUSION: Insulin and insulin resistance levels are associated with POP in women with GDM with different modes of delivery, and their combined assessment may increase the predictive value for POP.