Impact of subclinical hypothyroidism and thyroid autoimmunity on clinical pregnancy rate after intrauterine insemination in euthyroid women.

OBJECTIVE

This study aimed to evaluate the association between subclinical hypothyroidism and thyroid autoantibodies with clinical pregnancy rate after intrauterine insemination (IUI) in euthyroid women.

METHODS

In this prospective cohort study, we recruited 497 women who underwent IUI treatment. We assessed thyroid function tests, thyroid antibodies and clinical pregnancy rates of the patients.

RESULTS

The patients were divided into two groups according to TSH values: normal group, n=387, and subclinical hypothyroidism group 2, n=110. The clinical pregnancy rate was 15.2% in the Control Group and 17.3% in the study group (p=0.656). In the Study Group, 35% of the patients had anti-TPO positivity (p=0.531) and 42.1% of the patients had anti-TG positivity (p=0.285). There was no statistically significant difference in clinical pregnancy rates between the groups in terms of antithyroid antibody positivity (p=0.54; p=0.559, respectively).

CONCLUSION

Anti-TPO antibodies and subclinical hypothyroidism had no impact on clinical pregnancy rates in the women submitted to IUI.