[Significance of morphofunctional assessment of tissue basophil reactions in prognostication of harmful effects of chemical substances].

The article contains a comparative analysis of experimental data on the assessment of the general toxicological, gonadotrophic effects and morphofunctional reactions of tissue basophils under the influence of 4-bromine-o-xylene, carbon disulfide and pyracryl. Established was the gonadotrophic action of pyracryl against the growing activity of tissue basophils manifested through increased infiltration and high-level degranulation in female rats' reproductive organs. Demonstrated was that, under the influence of low-intensity chemical factors, tissue basophils morphofunctional reactions were those of organ-related nature. The quantitative assessment of tissue basophils was proposed as an informative model for studies of selective (gonadotrophic) actions of low-intensity chemical substances.