Advancements in small molecule fluorescent probes for the detection of formaldehyde in environmental and food samples: A comprehensive review.

Formaldehyde (FA), a hazardous substance with carcinogenicity and mutagenicity, necessitates sensitive and accurate detection methods for protecting public health and the environment. While numerous reviews have explored FA fluorescent probes, the current literature predominantly emphasizes biological systems, leaving a gap in addressing FA's roles in environmental monitoring and food safety. This review discusses recognition mechanisms for FA detection, including 2-aza-Cope rearrangement, methylenehydrazine reaction, formimine formation, and other mechanisms. Furthermore, this review underscores the practical applications of these probes in real-world contexts, namely their incorporation into test strips, hydrogels, and membranes for environmental monitoring and food safety. Moreover, this review highlights future directions for developing intelligent detection systems that combine fluorescent probes with data processing algorithms and artificial intelligence technologies. By synthesizing the current knowledge in this area, this review aims to stimulate future research and advancements in FA detection technology, ultimately contributing to improved environmental management and public health protection.