Fertility and sterility · 2003
Poor response after hormonal stimulation for in vitro fertilization is not related to ovarian aging.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
De Sutter Paul, Dhont Marc
Аннотация
OBJECTIVE: To investigate whether the diminished efficacy of ART in young poor responders compared to young normal responders is due to a quantitative or a qualitative oocyte factor.
DESIGN: Retrospective comparative analysis.
SETTING: University-based infertility center.
PATIENT(S): Nine thousand six hundred forty-four patients who underwent ART procedures at our hospital from 1993 until 2001.
INTERVENTION(S): Controlled ovarian hyperstimulation, ultrasonographic monitoring of the ovarian response, oocyte retrieval, ART procedure, embryo transfer, and follow-up of pregnant patients until 12 weeks of amenorrhea.
MAIN OUTCOME MEASURES: Clinical rates of pregnancy and miscarriage.
RESULT(S): Nine thousand six hundred forty-four ART cycles were analyzed. The pregnancy rate for poor responders was significantly lower than for normal responders (17% vs. 35%). In cycles in which two good-quality embryos were transferred, the pregnancy rate was similar in poor responders and normal responders (33% vs. 42%). The rate of miscarriage was no higher in poor responders than normal responders.
CONCLUSION(S): Young poor responders have a lower pregnancy rate than young normal responders because they have fewer oocytes, which leads to fewer good-quality embryos to choose from for transfer. The quality of their oocytes and embryos is not inferior to that of normal responders.
DESIGN: Retrospective comparative analysis.
SETTING: University-based infertility center.
PATIENT(S): Nine thousand six hundred forty-four patients who underwent ART procedures at our hospital from 1993 until 2001.
INTERVENTION(S): Controlled ovarian hyperstimulation, ultrasonographic monitoring of the ovarian response, oocyte retrieval, ART procedure, embryo transfer, and follow-up of pregnant patients until 12 weeks of amenorrhea.
MAIN OUTCOME MEASURES: Clinical rates of pregnancy and miscarriage.
RESULT(S): Nine thousand six hundred forty-four ART cycles were analyzed. The pregnancy rate for poor responders was significantly lower than for normal responders (17% vs. 35%). In cycles in which two good-quality embryos were transferred, the pregnancy rate was similar in poor responders and normal responders (33% vs. 42%). The rate of miscarriage was no higher in poor responders than normal responders.
CONCLUSION(S): Young poor responders have a lower pregnancy rate than young normal responders because they have fewer oocytes, which leads to fewer good-quality embryos to choose from for transfer. The quality of their oocytes and embryos is not inferior to that of normal responders.