Medicine · 2022
Anti-N-methyl-D-aspartate receptor encephalitis after coronavirus disease 2019: A case report and literature review.
Клинический случайСтатьяОбзорНазвание и аннотация: Перевод в очереди
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Lee Hyesun, Jeon Jong Hyun, Choi Hojin, Koh Seong-Ho, Lee Kyu-Yong, Lee Young Joo, Kwon Hyuk Sung
Аннотация
RATIONALE: Coronavirus disease 2019 (COVID-19) has become a global pandemic and COVID-19-associated anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis may occur through an immune-mediated pathomechanism.
PATIENT CONCERNS: A 21-year-old woman with a history of COVID-19 presented to our hospital with memory decline and psychiatric symptoms.
DIAGNOSIS: The patient was diagnosed with anti-NMDAR encephalitis.
INTERVENTION: Intravenous methylprednisolone (1 g/day over 5 days) followed by immunoglobulin (0.4 g/kg/day over 5 days) were administered. The patient underwent laparoscopic salpingo-oophorectomy to remove an ovarian teratoma.
OUTCOMES: The patient was discharged with sequelae of short-term memory impairment, without other neuropsychiatric symptoms.
LESSONS: Cases of previously reported anti-NMDAR encephalitis with COVID-19 were reviewed and compared with the present case. Clinicians should be aware of the occurrence of anti-NMDAR encephalitis in patients who present with neuropsychiatric complaints during or after exposure to COVID-19. Further studies are required to determine the causal relationship between the 2 diseases and predict the prognosis of anti-NMDAR encephalitis after COVID-19 exposure.
PATIENT CONCERNS: A 21-year-old woman with a history of COVID-19 presented to our hospital with memory decline and psychiatric symptoms.
DIAGNOSIS: The patient was diagnosed with anti-NMDAR encephalitis.
INTERVENTION: Intravenous methylprednisolone (1 g/day over 5 days) followed by immunoglobulin (0.4 g/kg/day over 5 days) were administered. The patient underwent laparoscopic salpingo-oophorectomy to remove an ovarian teratoma.
OUTCOMES: The patient was discharged with sequelae of short-term memory impairment, without other neuropsychiatric symptoms.
LESSONS: Cases of previously reported anti-NMDAR encephalitis with COVID-19 were reviewed and compared with the present case. Clinicians should be aware of the occurrence of anti-NMDAR encephalitis in patients who present with neuropsychiatric complaints during or after exposure to COVID-19. Further studies are required to determine the causal relationship between the 2 diseases and predict the prognosis of anti-NMDAR encephalitis after COVID-19 exposure.