Experimental feasibility of xenon-enhanced dual-energy radiography for imaging of lung function.

Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide. We experimentally investigated the feasibility of two-dimensional xenon-enhanced dual-energy (XeDE) radiography for imaging of lung function. We optimized image quality under quantum-noise-limited conditions using a chest phantom consisting of a rectangular chamber representing the thoracic volume and PMMA slabs simulating x-ray attenuation by soft tissue. A sealed, air-filled cavity with thin PMMA walls was positioned inside the chamber to simulate a 2 cm thick ventilation defect. The chamber was ventilated with xenon and dual-energy imaging was performed using a diagnostic x-ray tube and a flat-panel detector. The contrast-to-noise ratio of ventilation defects normalized by patient x-ray exposure maximized at a kV-pair of approximately 60/140-kV and when approximately one third of the total exposure was allocated to the HE image. We used the optimized technique to image a second phantom that contained lung-parenchyma-mimicking PMMA clutter, rib-mimicking aluminum slats and an insert that simulated ventilation defects with thicknesses ranging from 0.5 cm to 2 cm and diameters ranging from 1 cm to 2 cm. From the resulting images we computed the area under the receiver operating characteristic curve (AUC) of the non-prewhitening model observer with an eye filter and internal noise. For a xenon concentration of 75%, good AUCs (i.e. 0.8-0.9) to excellent AUCs (i.e. >0.9) were obtained when the defect diameter is greater than 1.3 cm and defect thickness is 1 cm. When the xenon concentration was reduced to 50%, the AUC was ∼0.9 for defects 1.2 cm in diameter and ∼1.5 cm in thickness. Two-dimensional XeDE radiography may therefore enable detection of functional abnormalities associated with early-stage COPD, for which xenon ventilation defects can occupy up to 20% of the lung volume, and should be further developed as a low-cost alternative to MRI-based approaches and a low-dose alternative to CT-based approaches.