Fertility and sterility · 1997
Prenatal diagnosis of ring chromosome 14 after intracytoplasmic sperm injection.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Jean M, Rival J M, Mensier A, Mirallié S, Lopes P, Barrière P
Аннотация
OBJECTIVE: To collect extensively abnormal cytogenetic results in pregnancies obtained after intracytoplasmic sperm injection (ICSI).
DESIGN: Case report.
SETTING: University Hospital of Nantes, France.
PATIENT(S): A couple with 5 years of primary infertility and severe male factor undergoing ICSI procedure.
INTERVENTION(S): Ultrasound-guided transvaginal follicular aspiration, amniocentesis, and medical abortion.
MAIN OUTCOME MEASURE(S): Serum levels of E2, beta-hCG, and fetal chromosomal karyotype.
RESULT(S): Ultrasonic observation at 12 weeks revealed an 8-mm thick cystic hygroma in the nuchal area. Because the karyotypic analysis was [46,XX,r(14)/45,XX,-14], medical abortion was performed at 14 weeks, after the patients gave their informed consent.
CONCLUSION(S): According to the prevalence of this unusual chromosomal abnormality in humans, such abnormal cytogenetic results have to be collected extensively to assess the feasibility of using ICSI procedure.
DESIGN: Case report.
SETTING: University Hospital of Nantes, France.
PATIENT(S): A couple with 5 years of primary infertility and severe male factor undergoing ICSI procedure.
INTERVENTION(S): Ultrasound-guided transvaginal follicular aspiration, amniocentesis, and medical abortion.
MAIN OUTCOME MEASURE(S): Serum levels of E2, beta-hCG, and fetal chromosomal karyotype.
RESULT(S): Ultrasonic observation at 12 weeks revealed an 8-mm thick cystic hygroma in the nuchal area. Because the karyotypic analysis was [46,XX,r(14)/45,XX,-14], medical abortion was performed at 14 weeks, after the patients gave their informed consent.
CONCLUSION(S): According to the prevalence of this unusual chromosomal abnormality in humans, such abnormal cytogenetic results have to be collected extensively to assess the feasibility of using ICSI procedure.