AJNR. American journal of neuroradiology · 2026
Assessing optic nerve integrity in optic neuritis with conventional magnetic resonance imaging.
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Sánchez-Ulloa Helena, Mongay-Ochoa Neus, Alberich Manel, Ajdinaj Paola, Funelli Eugenio, Braga Nathane, Rodríguez-Acevedo Breogán, Cabello Sergio, Moncho Dulce, Sceppacuercia Sofía, Auger Cristina, Tintoré Mar, Montalban Xavier, Vidal-Jordana Angela, Piella Gemma, Rovira Àlex, Pareto Deborah, Sastre-Garriga Jaume
Аннотация
BACKGROUND AND PURPOSE: The aim of this study was to investigate the integrity of the optic nerve using the ratio between T1WI and T2WI (T1/T2) MRI signal intensities, and to assess whether inter-eye differences could indicate the presence of lesions in the optic nerve.
MATERIAL AND METHODS: The cohort included eighteen healthy controls and forty-nine individuals with multiple sclerosis; from those, thirty-two had a previous episode of optic neuritis. A method was trained to generate automatic segmentations of the optic nerve. Provided masks were then applied to the T1/T2 map and the mean profile was extracted. Inter-eye asymmetry was calculated from the area under the profiles. The presence of optic nerve lesions was confirmed using double inversion recovery MRI. Group differences were evaluated with non-parametric statistical tests, and the ability of inter-eye asymmetry to identify lesions was assessed using logistic regression.
RESULTS: Automated masks showed a moderate agreement with the reference segmentations (mean Dice coefficient ± SD = 0.53 ± 0.12). Eyes with a visible lesion on MRI showed a significantly lower T1/T2 (mean ± SD = 0.61 ± 0.09) compared to other groups (multiple sclerosis without optic neuritis 0.74 ± 0.06, p<0.001; and healthy subjects 0.77 ± 0.09, p<0.001). Inter-eye asymmetry demonstrated a good discriminative performance, with an area under the curve of 0.83, a sensitivity of 0.74, and a specificity of 0.82.
CONCLUSION: The findings indicate that conventional MRI can provide clinically meaningful information regarding optic nerve integrity and support the development of automated tools for detecting optic nerve lesions.
MATERIAL AND METHODS: The cohort included eighteen healthy controls and forty-nine individuals with multiple sclerosis; from those, thirty-two had a previous episode of optic neuritis. A method was trained to generate automatic segmentations of the optic nerve. Provided masks were then applied to the T1/T2 map and the mean profile was extracted. Inter-eye asymmetry was calculated from the area under the profiles. The presence of optic nerve lesions was confirmed using double inversion recovery MRI. Group differences were evaluated with non-parametric statistical tests, and the ability of inter-eye asymmetry to identify lesions was assessed using logistic regression.
RESULTS: Automated masks showed a moderate agreement with the reference segmentations (mean Dice coefficient ± SD = 0.53 ± 0.12). Eyes with a visible lesion on MRI showed a significantly lower T1/T2 (mean ± SD = 0.61 ± 0.09) compared to other groups (multiple sclerosis without optic neuritis 0.74 ± 0.06, p<0.001; and healthy subjects 0.77 ± 0.09, p<0.001). Inter-eye asymmetry demonstrated a good discriminative performance, with an area under the curve of 0.83, a sensitivity of 0.74, and a specificity of 0.82.
CONCLUSION: The findings indicate that conventional MRI can provide clinically meaningful information regarding optic nerve integrity and support the development of automated tools for detecting optic nerve lesions.