Archives of physiology and biochemistry · 2024
Boldine reduces left ventricle oxidative stress in isoproterenol-induced adrenergic overload experimental model.
СтатьяНазвание и аннотация: Перевод в очереди
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Kerli Fernandes Elissa, Türck Patrick, Campos Carraro Cristina, Tasca Silvio, Teixeira Proença Isabel Cristina, Palma Victor De Mello, Visioli Fernanda, Torres Iraci Lucena Da Silva, Belló-Klein Adriane, Luz De Castro Alexandre, Da Rosa Araujo Alex Sander
Аннотация
Sustained adrenergic overload in the heart causes maladaptive cardiac remodelling, which involves oxidative stress. Boldine (BOL) has antioxidant activity and represents a novel therapeutic approach. This study explored the cardioprotective role of BOL in adverse left ventricular remodelling induced by isoproterenol. The rats were divided into four groups: control; BOL (25 mg/kg daily); isoproterenol (ISO) (5 mg/kg daily), and ISO + BOL. Morphometric, echocardiographic, and oxidative stress parameters were evaluated. BOL attenuated both cardiac hypertrophy and increased diastolic volume caused by adrenergic overstimulation (P < 0.05). BOL treatment reduced lipid peroxidation induced by ISO (ISO vs. ISO + BOL; P < 0.05), and this effect was associated with increased superoxide dismutase (SOD) (ISO vs. ISO + BOL; P < 0.05) and glutathione-S-transferase levels (GST) (ISO vs. ISO + BOL; P < 0.05). This data suggest that BOL may improve cardiac oxidative stress and attenuate some parameters of adverse cardiac remodelling.