Drug design, development and therapy · 2024
Comparison of the Effects of Ciprofol and Propofol on Postoperative Nausea and Vomiting in Patients Undergoing Outpatient Hysteroscopy.
СтатьяРандомизированное исследованиеСравнительное исследованиеНазвание и аннотация: Перевод в очереди
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Zhang Huaming, Zhang Min, Hao Lina, Li Qianqian, Li Qijian, Yang Jia, Xie Yanhu
Аннотация
PURPOSE: To evaluate and compare the effects of ciprofol and propofol on postoperative nausea and vomiting (PONV) in patients undergoing outpatient hysteroscopy.
DESIGN: Double-blind randomized controlled trial.
METHODS: This study included 1104 patients scheduled for elective outpatient hysteroscopy. Patients were randomly grouped to ciprofol Group (Group C, n = 539) and propofol Group (Group P, n = 547). Anesthesia was induced by sufentanil 0.1 ug/kg combined with ciprofol 0.3mg/kg or propofol 2.5mg/kg. Anesthesia was maintained by ciprofol 1 to 1.5mg/kg/h or propofol 3 to 5mg/kg/h. The primary outcome of the study was PONV after surgery 1h and 24h. Secondary outcomes included heart rate (HR), mean arterial blood pressure (MAP), SpO2 before anesthesia (T1), 3 min after anesthesia (T2) and at the end of surgery (T3); the time of consciousness loss, recovery, hysteroscopy and discharge; and the incidence of adverse drug reactions such as hypotension, respiratory depression, bradycardia and injection pain was recorded in the two groups.
RESULTS: Compared with group P, MAP and SpO2 at T2 were significantly increased in group C (P<0.05). Although there was no significant difference in the incidence of PONV at 1h and 24h after surgery between 2 groups (P > 0.05), the incidence of hypotension, injection pain and respiratory depression in group C were significantly reduced, compared with group P. (P<0.05).
CONCLUSION: Compared with propofol, ciprofol has a similar incidence of PONV and lower adverse effects such as hypotension, injection pain and respiratory depression in outpatient hysteroscopy.
DESIGN: Double-blind randomized controlled trial.
METHODS: This study included 1104 patients scheduled for elective outpatient hysteroscopy. Patients were randomly grouped to ciprofol Group (Group C, n = 539) and propofol Group (Group P, n = 547). Anesthesia was induced by sufentanil 0.1 ug/kg combined with ciprofol 0.3mg/kg or propofol 2.5mg/kg. Anesthesia was maintained by ciprofol 1 to 1.5mg/kg/h or propofol 3 to 5mg/kg/h. The primary outcome of the study was PONV after surgery 1h and 24h. Secondary outcomes included heart rate (HR), mean arterial blood pressure (MAP), SpO2 before anesthesia (T1), 3 min after anesthesia (T2) and at the end of surgery (T3); the time of consciousness loss, recovery, hysteroscopy and discharge; and the incidence of adverse drug reactions such as hypotension, respiratory depression, bradycardia and injection pain was recorded in the two groups.
RESULTS: Compared with group P, MAP and SpO2 at T2 were significantly increased in group C (P<0.05). Although there was no significant difference in the incidence of PONV at 1h and 24h after surgery between 2 groups (P > 0.05), the incidence of hypotension, injection pain and respiratory depression in group C were significantly reduced, compared with group P. (P<0.05).
CONCLUSION: Compared with propofol, ciprofol has a similar incidence of PONV and lower adverse effects such as hypotension, injection pain and respiratory depression in outpatient hysteroscopy.