Journal of clinical anesthesia · 2024
Effect of inspiratory oxygen fraction during driving pressure-guided ventilation strategy on pulmonary complications following open abdominal surgery: A randomized controlled trial.
СтатьяРандомизированное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Zhang Yu-Tong, Han Yang, Zhuang Hui-Jia, Feng Ai-Min, Jin Liang, Li Xue-Fei, Yu Hong, Yu Hai
Аннотация
STUDY OBJECTIVE: The aim of the present study was to determine the effect of 30 % fraction of inspired oxygen (FIO2) compared with 80 % FIO2 in the context of driving pressure-guided ventilation strategy on pulmonary complications following open abdominal surgery.
DESIGN: A single-center, prospective, randomized controlled trial.
SETTING: Tertiary university hospital in China.
PATIENTS: 514 adult patients, ASA I-III and scheduled for major open abdominal surgery under general anesthesia.
INTERVENTIONS: Patients were randomly assigned to receive either 30 % or 80 % FIO2 during the intraoperative period. All patients received driving pressure-guided ventilation strategy, including low tidal volume and individualized PEEP set at lowest driving pressure.
MEASUREMENTS: The primary outcome was the incidence of a composite of pulmonary complications within the 7 days postoperatively. The severity of pulmonary complications, extrapulmonary complications, and other secondary outcomes were also assessed.
MAIN RESULTS: Of 1553 patients assessed for eligibility, 514 patients were randomly assigned and analyzed with intention-to-treat principle. Patients receiving 30 % FIO2 had a significantly lower incidence of postoperative pulmonary complications (PPCs) compared to those receiving 80 % FIO2 (46.3 %vs. 64.6 %; RR, 0.72; 95 % CI, 0.61-0.84; P < 0.001). The severity score of PPCs was significantly reduced in the 30 % FIO2 group compared with that in the 80 % FIO2 group within the 7 postoperative days (P < 0.001). Dynamic compliance was significantly greater in 30 % FIO2 group at the end of surgery (56 [48-66] vs. 53 [46-62], P = 0.027). More patients in the 80 % FIO2 group developed oxygen desaturation (SpO2 < 94 %) on air intake during PACU stay (18.5 %vs. 30.4 %; RR, 0.61; 95 % CI, 0.44-0.84; P = 0.002; 30 % FIO2 group vs.80 % FIO2 group).
CONCLUSIONS: In patients undergoing open abdominal surgery, using a 30 % FIO2, compared with 80 % FIO2, in context of driving pressure-guided ventilation strategy, intraoperatively reduced the incidence and severity of pulmonary complications within the first 7 postoperative days.
DESIGN: A single-center, prospective, randomized controlled trial.
SETTING: Tertiary university hospital in China.
PATIENTS: 514 adult patients, ASA I-III and scheduled for major open abdominal surgery under general anesthesia.
INTERVENTIONS: Patients were randomly assigned to receive either 30 % or 80 % FIO2 during the intraoperative period. All patients received driving pressure-guided ventilation strategy, including low tidal volume and individualized PEEP set at lowest driving pressure.
MEASUREMENTS: The primary outcome was the incidence of a composite of pulmonary complications within the 7 days postoperatively. The severity of pulmonary complications, extrapulmonary complications, and other secondary outcomes were also assessed.
MAIN RESULTS: Of 1553 patients assessed for eligibility, 514 patients were randomly assigned and analyzed with intention-to-treat principle. Patients receiving 30 % FIO2 had a significantly lower incidence of postoperative pulmonary complications (PPCs) compared to those receiving 80 % FIO2 (46.3 %vs. 64.6 %; RR, 0.72; 95 % CI, 0.61-0.84; P < 0.001). The severity score of PPCs was significantly reduced in the 30 % FIO2 group compared with that in the 80 % FIO2 group within the 7 postoperative days (P < 0.001). Dynamic compliance was significantly greater in 30 % FIO2 group at the end of surgery (56 [48-66] vs. 53 [46-62], P = 0.027). More patients in the 80 % FIO2 group developed oxygen desaturation (SpO2 < 94 %) on air intake during PACU stay (18.5 %vs. 30.4 %; RR, 0.61; 95 % CI, 0.44-0.84; P = 0.002; 30 % FIO2 group vs.80 % FIO2 group).
CONCLUSIONS: In patients undergoing open abdominal surgery, using a 30 % FIO2, compared with 80 % FIO2, in context of driving pressure-guided ventilation strategy, intraoperatively reduced the incidence and severity of pulmonary complications within the first 7 postoperative days.