Palladium-Catalyzed Cascade Cross-Coupling/Retro-Claisen Reaction of CF3-Substituted β-Diketones with gem-Difluorocyclopropanes.

A palladium-catalyzed cascade coupling/retro-Claisen reaction of CF3-substituted β-diketones with readily available gem-difluorocyclopropanes has been developed. This methodology allows for the expedient synthesis of γ-fluorinated γ,δ-unsaturated ketones in a one-pot procedure with a broad scope and good to excellent yields.