Pain intensity after robotic-assisted urological surgery: the PAIROU study an international prospective cohort study.
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Rouxel Pauline, Rayon Emilien, Bellocq Anne-Sophie, le Guen Morgan, Fessler Julien, Cirenei Cédric, Blondonnet Raïko, Parfait Emmanuel, Patrubani Ana-Gabriela, Ramorasata Andersen, Gouel Aurélie, Brogly Nicolas, Devoldere Guillaume, Dupont Mélanie, Gaultier Elodie, Dupuis Martin, Bouzat Pierre, Cattenoz Mathilde, Prieur Sophie, Cuvillon Philippe, Gricourt Yann, Pastene Bruno, Huette Pierre, Garot Matthias, Ramarosaona Andry, Massin Rémi, Grailles Guillaume, Rollé Amélie, Daouda Ibrahim Moussa, Boinette Romain, Birckener Julien, Habrial Pierre, Samaha Toufik, Lemoine Adrien, Damon Alexandre, Rodriguez Marie, Braun Thierry, Fritsch Marine, Tawil Sahfouane, Guerin Vincent, Lagrave-Blampied Laure, Ravry Céline, Poette Michael, Tao-Mauny Stéphanie, Mfam Willy-Serge, Fontaine Matthieu, Boutouria Mehrez, Deffar Nordine, Sigwalt Florent, Thiltges Laurent, Ionescu Mirela, Diaz-Pache Maria Victoria Acedo, Perez Rosalia Navarro, Caragliano Gianluca, Profumo Louis, Peyronnet Benoit, Renault Alain, Joosten Alexandre, Beloeil Helene, PAIROU group and French Society of Anesthesiologists (SFAR) Research Network
Аннотация
METHODS: This was a prospective, multicentre, observational trial in 44 centers in Europe that included patients scheduled for robotic-assisted urological surgery. The primary outcome was pain scores on the first day after surgery assessed using the numeric rating scale (NRS). Secondary outcomes included pain score on the second day after surgery, morphine equivalent consumption in mg 48 h after the surgery, postoperative nausea and vomiting (PONV), and surgical complications.
RESULTS: A total of 965 patients were recruited between November 2022 and June 2023. Median pain score on postoperative day 1 was 2 at rest (IQR, 0-4) (n = 963) and 3 with movement (IQR, 1-5) (n = 921). Morphine equivalent consumption 48 h after the surgery was 4 mg (IQR 0-20 mg). PONV was experienced by 16 % of the patients (153/963).
CONCLUSION: This large cohort study demonstrates that patients experience low pain scores and require low opioids after robotic-assisted urological surgery when commonly used multimodal analgesia protocols are administered.
TRIAL REGISTRATION: clinicaltrials.gov No. NCT05575284.