Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025
Cerebellar grey matter volume predicts cerebellar tDCS efficacy in individuals with Friedreich ataxia.
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Naeije Gilles, Georgiev Christian, Cabaraux Pierre, Bourguignon Mathieu
Аннотация
OBJECTIVE: To determine the impact of cerebellar anatomy on ctDCS efficacy in individuals with Friedreich ataxia (FA).
METHODS: We included 24 FA patients (mean age 31 ± 14 years) and 24 age- and sex-matched healthy controls. Patients underwent a 5-day ctDCS intervention, with cerebellar motor and non-motor symptoms assessed using the Scale for the Assessment and Rating of Ataxia (SARA) and the Cerebellar Cognitive Affective Syndrome Scale (CCAS-S), before and after stimulation. MRI was used to measure cerebellar gray matter volume, superior cerebellar peduncle (SCP) diameter, and skin-to-cerebellum distance. Stepwise linear regression analyses examined predictors of motor and cognitive improvements following ctDCS.
RESULTS: FA patients exhibited significantly reduced cerebellar gray matter volume compared to controls (p = 0.024) after intracranial volume correction, skin-to-cerebellum distance did not differ between groups (p = 0.11). Stepwise linear regression analysis disclosed that the anterior cerebellar gray matter volume was a significant predictor of SARA improvement (β = -0.18, p < 0.001) and the posterior cerebellar gray matter volume of CCAS-S improvement (β = -0.13, p 0.023). Neither SCP diameter nor skin-to-cerebellum distance significantly impacted ctDCS efficacy.
CONCLUSION: Cerebellar gray matter volume is associated to ctDCS-induced symptoms improvements in FA.
SIGNIFICANCE: These findings suggest that cerebellar gray matter volume influences ctDCS responsiveness.
METHODS: We included 24 FA patients (mean age 31 ± 14 years) and 24 age- and sex-matched healthy controls. Patients underwent a 5-day ctDCS intervention, with cerebellar motor and non-motor symptoms assessed using the Scale for the Assessment and Rating of Ataxia (SARA) and the Cerebellar Cognitive Affective Syndrome Scale (CCAS-S), before and after stimulation. MRI was used to measure cerebellar gray matter volume, superior cerebellar peduncle (SCP) diameter, and skin-to-cerebellum distance. Stepwise linear regression analyses examined predictors of motor and cognitive improvements following ctDCS.
RESULTS: FA patients exhibited significantly reduced cerebellar gray matter volume compared to controls (p = 0.024) after intracranial volume correction, skin-to-cerebellum distance did not differ between groups (p = 0.11). Stepwise linear regression analysis disclosed that the anterior cerebellar gray matter volume was a significant predictor of SARA improvement (β = -0.18, p < 0.001) and the posterior cerebellar gray matter volume of CCAS-S improvement (β = -0.13, p 0.023). Neither SCP diameter nor skin-to-cerebellum distance significantly impacted ctDCS efficacy.
CONCLUSION: Cerebellar gray matter volume is associated to ctDCS-induced symptoms improvements in FA.
SIGNIFICANCE: These findings suggest that cerebellar gray matter volume influences ctDCS responsiveness.