Blood purification · 2015
Lower serum magnesium is associated with cardiovascular risk factors and mortality in haemodialysis patients.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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João Matias Patrícia, Azevedo Ana, Laranjinha Ivo, Navarro David, Mendes Marco, Ferreira Carina, Amaral Tiago, Jorge Cristina, Aires Inês, Gil Célia, Ferreira Aníbal
Аннотация
BACKGROUND: Hypomagnesaemia is a cardiovascular (CV) risk factor in the general population. The aim of this study was to evaluate the relationship between pre-dialysis magnesium (Mg) and CV risk markers, [including pulse pressure (PP), left ventricular mass index (LVMI) and vascular calcifications (VC)], and mortality in haemodialysis (HD) patients.
METHODS: We performed a 48-month prospective study in 206 patients under pre-dilution haemodiafiltration with a dialysate Mg concentration of 1 mmol/l.
RESULTS: Lower Mg concentrations were predictors of an increased PP (≥65 mm Hg) (p = 0.002) and LVMI (≥140 g/m(2)) (p = 0.03) and of a higher VC score (≥3) (p = 0.01). Patients with Mg <1.15 mmol/l had a lower survival at the end of the study (p = 0.01). Serum Mg <1.15 mmol/l was an independent predictor of all-cause (p = 0.01) and CV mortality (p = 0.02) when adjusted for multiple CV risk factors.
CONCLUSIONS: Lower Mg levels seem to be associated with increased CV risk markers, like PP, LVMI and VC, and with higher mortality in HD patients.
METHODS: We performed a 48-month prospective study in 206 patients under pre-dilution haemodiafiltration with a dialysate Mg concentration of 1 mmol/l.
RESULTS: Lower Mg concentrations were predictors of an increased PP (≥65 mm Hg) (p = 0.002) and LVMI (≥140 g/m(2)) (p = 0.03) and of a higher VC score (≥3) (p = 0.01). Patients with Mg <1.15 mmol/l had a lower survival at the end of the study (p = 0.01). Serum Mg <1.15 mmol/l was an independent predictor of all-cause (p = 0.01) and CV mortality (p = 0.02) when adjusted for multiple CV risk factors.
CONCLUSIONS: Lower Mg levels seem to be associated with increased CV risk markers, like PP, LVMI and VC, and with higher mortality in HD patients.
Предметные рубрики MeSH
AgedBlood PressureCalciumCardiovascular DiseasesCause of DeathChelating AgentsCoronary DiseaseDiabetes ComplicationsDiureticsFemaleHumansHypertrophy, Left VentricularKidney Failure, ChronicMagnesiumMagnesium DeficiencyMaleMiddle AgedMortalityProportional Hazards ModelsProspective StudiesProton Pump InhibitorsRenal DialysisRisk FactorsSurvival RateVascular CalcificationVitamin D