Ultrasensitive colorimetric assay of cadmium ion based on silver nanoparticles functionalized with 5-sulfosalicylic acid for wide practical applications.

Low-level cadmium ion (Cd(2+)) exposure contributes much toward the causation of chronic disease. Due to its low permissible exposure limit, overexposures may occur even in situations where trace quantities of Cd(2+) exist. So far, no effective treatment for Cd(2+) toxicity has been reported. Prevention of further exposure is the most important step in management of patients suggestive of Cd(2+) intoxication. Development of sensors for Cd(2+) is of great interest to ensure early diagnosis and improve management. We propose here a simple, low-cost (0.1$ per sample) yet very sensitive (limit of detection is 3.0 nM) and selective colorimetric assay for rapid (2 min) determination of Cd(2+) based on 5-sulfosalicylic acid functionalized silver nanoparticles (SAA-AgNPs). This method shows excellent selectivity for Cd(2+) over the other 16 metal ions. It is also precise and highly reproducible in determining Cd(2+) in real samples such as tap water, milk, serum, and urine with recoveries ranging from 93 to 110%, indicating the wide practical application to samples suspected of Cd(2+) exposure.