Glymphatic clearance as revealed by diffusion tensor imaging along the perivascular space (DTI-ALPS) is associated with Alzheimer's disease neuropathology and periodic rsEEG alpha rhythms in mild cognitive impairment participants.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Lopez Susanna, Del Percio Claudio, Lizio Roberta, Noce Giuseppe, Carpi Matteo, Arnaldi Dario, Famà Francesco, Pardini Matteo, Massa Federico, Marinozzi Franco, Bini Fabiano, Treves Giorgia, Soricelli Andrea, Salvatore Marco, Giubilei Franco, Ziccardi Laura, Güntekin Bahar, Yener Görsev, Ferri Raffaele, Lanuzza Bartolo, Stocchi Fabrizio, Vacca Laura, Coletti Chiara, Infarinato Francesco, Romano Paola, Marizzoni Moira, Frisoni Giovanni B, Barone Paolo, Cappiello Arianna, Cuoco Sofia, Bonanni Laura, D'Anselmo Anita, Antonini Angelo, Fiorenzato Eleonora, Cauzzo Simone, Biundo Roberta, D'Antonio Fabrizia, De Pandis Maria Francesca, Marziali Simone, Bruno Giuseppe, Carducci Filippo, Babiloni Claudio
Аннотация
METHODS: Clinical, neuroimaging, and rsEEG data were analyzed in matched mild cognitive impairment due to AD (ADMCI) and MCI not due to AD (noADMCI) participants. DTI-ALPS index and aperiodic and periodic components of the rsEEG power spectra were calculated following standard pipelines.
RESULTS: Lower DTI-ALPS index was associated with higher AD neuropathology and WM lesions, lower periodic rsEEG alpha rhythms, and worse cognition in patients with ADMCI and noADMCI as a whole population, with the ADMCI (over noADMCI) group showing lower DTI-ALPS index, greater AD neuropathology, and lower periodic rsEEG alpha rhythms.
CONCLUSIONS: The DTI-ALPS index may capture glymphatic system impairment linked to AD neuropathology, vigilance dysfunction, and cognitive decline in MCI.