[DNA content examination for atypical hyperplasia of adenosis and carcinoma of the breast].

Nuclear DNA content of breast specimens in 80 cases was measured with microspectrophotometer. The results showed that there was no difference in the nuclear DNA content between normal breast and breast adenosis with epithelial hyperplasia grade I. The DNA content increased gradually with the development of atypical hyperplasia, while there was no difference in DNA content between breast adenosis with atypical hyperplasia grade III, malignant transformation of breast adenosis and breast cancer grade I. There was a statistically significant difference among the other groups. It was extremely important to measure nuclear DNA content in patients with atypical hyperplasia of the breast in order to study the precancerous lesion and to supervise clinically the tendency of cancerous.