Autonomic neuroscience : basic & clinical · 2025
Differences in muscle sympathetic nerve activity between patients with orthostatic hypertension and those with orthostatic normotensive hypertension.
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Hirai Tadayuki, Murai Hisayoshi, Sugimoto Hiroyuki, Mukai Yusuke, Tokuhisa Hideki, Ikeda Tatsunori, Kobayashi Daisuke, Takata Shigeo, Sakata Kenji, Usui Soichiro, Takamura Masayuki
Аннотация
Orthostatic hypertension (OrthoHT), an excessive pressor response to standing, increases cardiovascular risk; however, its relationship with sympathetic nerve activity is poorly understood. This study aimed to assess differences in muscle sympathetic nerve activity (MSNA) between patients with OrthoHT and those with orthostatic normotensive hypertension. We measured resting MSNA in seven patients with OrthoHT and 11 matched controls. The OrthoHT group exhibited significantly elevated MSNA burst frequency (38.4 ± 12.2 vs. 28.3 ± 5.7 bursts/min, P < 0.05) and burst incidence (61.1 ± 21.3 vs. 44.6 ± 11.1 bursts/100 heartbeats, P < 0.05). In conclusion, OrthoHT is strongly associated with sympathetic hyperactivity at rest, suggesting that this may be a key physiological mechanism contributing to the increased cardiovascular risk observed in these patients.