American journal of obstetrics and gynecology · 2005
N-acetyl-transferase phenotype and risk for preeclampsia.
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Zusterzeel Petra L M, te Morsche René H M, Raijmakers Maarten T M, Roes Eva Maria, Peters Wilbert H M, Steegers-Theunissen Régine P M, Steegers Eric A P
Аннотация
OBJECTIVE: This study was undertaken to determine whether the N-acetyltransferase (NAT) phenotype contributes to the susceptibility for the development of preeclampsia.
STUDY DESIGN: The NAT acetylator status was determined by measuring urinary caffeine metabolites in 134 nonpregnant women with a history of preeclampsia and in 109 control women with uncomplicated pregnancy. The chi(2) and logistic regression analyses were used for statistical evaluation of differences in acetylator status.
RESULTS: Significantly more fast acetylators were found among the women with a history of preeclampsia (46.3%) than among the controls (25.4%). Fast acetylators showed an odds ratio of 2.5 (95% CI 1.4-4.3) for preeclampsia. No differences in the acetylator status were found between women with a history of preeclampsia only and those with the HELLP syndrome as well.
CONCLUSION: The fast NAT acetylator status, which may result in altered NAT detoxification capacity, is associated with preeclampsia.
STUDY DESIGN: The NAT acetylator status was determined by measuring urinary caffeine metabolites in 134 nonpregnant women with a history of preeclampsia and in 109 control women with uncomplicated pregnancy. The chi(2) and logistic regression analyses were used for statistical evaluation of differences in acetylator status.
RESULTS: Significantly more fast acetylators were found among the women with a history of preeclampsia (46.3%) than among the controls (25.4%). Fast acetylators showed an odds ratio of 2.5 (95% CI 1.4-4.3) for preeclampsia. No differences in the acetylator status were found between women with a history of preeclampsia only and those with the HELLP syndrome as well.
CONCLUSION: The fast NAT acetylator status, which may result in altered NAT detoxification capacity, is associated with preeclampsia.