Fertility and sterility · 2002
Influence of severe endometriosis on gene expression of vascular endothelial growth factor and interleukin-6 in granulosa cells from patients undergoing controlled ovarian hyperstimulation for in vitro fertilization-embryo transfer.
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Yamashita Yoshiki, Ueda Masatsugu, Takehara Mikio, Yamashita Hikari, Suzuki Yoshihiko, Hung Yao-Ching, Terai Yoshito, Ueki Minoru
Аннотация
OBJECTIVE: To evaluate how endometriosis affects expression of vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) in granulosa cells.
DESIGN: Prospective study.
SETTING: IVF-ET program at Osaka Medical College.
PATIENT(S): Seventeen patients with revised American Fertility Society stage IV endometriosis and 17 patients with tubal infertility and no endometriosis.
INTERVENTION(S): Granulosa cells obtained at oocyte retrieval were examined for VEGF and IL-6 gene expression.
MAIN OUTCOME MEASURE(S): Serum E(2) and P levels at hCG administration, number of oocytes, fertilization rate, high-quality embryo rate, and pregnancy rate, and expression of VEGF and IL-6 genes.
RESULT(S): Total hMG and FSH levels were statistically significantly higher in patients with endometriosis; however, the number of retrieved oocytes and the fertilization rate were lower compared with patients with tubal infertility. Serum E(2) levels and expression of VEGF in patients with tubal infertility were statistically significantly higher than those in patients with endometriosis. Interleukin-6 gene expression did not differ between the groups.
CONCLUSION(S): In severe endometriosis, lower VEGF gene expression in granulosa cells may adversely affect oocyte development and maturation.
DESIGN: Prospective study.
SETTING: IVF-ET program at Osaka Medical College.
PATIENT(S): Seventeen patients with revised American Fertility Society stage IV endometriosis and 17 patients with tubal infertility and no endometriosis.
INTERVENTION(S): Granulosa cells obtained at oocyte retrieval were examined for VEGF and IL-6 gene expression.
MAIN OUTCOME MEASURE(S): Serum E(2) and P levels at hCG administration, number of oocytes, fertilization rate, high-quality embryo rate, and pregnancy rate, and expression of VEGF and IL-6 genes.
RESULT(S): Total hMG and FSH levels were statistically significantly higher in patients with endometriosis; however, the number of retrieved oocytes and the fertilization rate were lower compared with patients with tubal infertility. Serum E(2) levels and expression of VEGF in patients with tubal infertility were statistically significantly higher than those in patients with endometriosis. Interleukin-6 gene expression did not differ between the groups.
CONCLUSION(S): In severe endometriosis, lower VEGF gene expression in granulosa cells may adversely affect oocyte development and maturation.
Предметные рубрики MeSH
Chorionic GonadotropinEmbryo TransferEndometriosisEndothelial Growth FactorsEstradiolFallopian Tube DiseasesFemaleFertilization in VitroFollicle Stimulating HormoneGene ExpressionGranulosa CellsHumansInfertility, FemaleIntercellular Signaling Peptides and ProteinsInterleukin-6LymphokinesMenotropinsOocytesOvulation InductionPolymerase Chain ReactionPregnancyProgesteroneProspective StudiesReproductive Techniques, AssistedVascular Endothelial Growth Factor AVascular Endothelial Growth Factors