Медицинская библиотека · BMJ global health · 2023

Post COVID sequelae among COVID-19 survivors: insights from the Indian National Clinical Registry for COVID-19.

Kumar Gunjan, Bhalla Ashish, Mukherjee Aparna, Turuk Alka, Talukdar Arunansu, Mukherjee Subhasis, Bhardwaj Pankaj, Menon Geetha R, Sahu Damodar, Misra Puspender, Sharma Lokesh Kumar, Mohindra Ritin, S Samita, Suri Vikas, Das Himadri, Sarkar Debasis, Ghosh Soumyadeep, Ghosh Priyanka, Dutta Moumita, Chakraborty Shreetama, Kumar Deepak, Gupta Manoj Kumar, Goel Akhil Dhanesh, Baruah Tridip Dutta, Kannauje Pankaj Kumar, Shukla Arvind Kumar, Khambholja Janakkumar R, Patel Amit, Shah Nitesh, Bhuniya Sourin, Panigrahi Manoj Kumar, Mohapatra Prasanta Raghab, Pathak Ashish, Sharma Ashish, John Mary, Kaur Kiranpreet, Nongpiur Vijay, Pala Star, Shivnitwar Sachin K, Krishna Bobba Rohil, Dulhani Naveen, Gupta Balkishan, Gupta Jigyasa, Bhandari Sudhir, Agrawal Abhishek, Aggarwal H K, Jain Deepak, Shah Arti D, Naik Parshwa, Panchal Manisha, Anderpa Mayank, Kikon Nyanthung, Humtsoe Christina Nzani, Sharma Nikita, Vohra Rajaat, Patnaik Lipilekha, Sahoo Jagdish Prasad, Joshi Rajnish, Kokane Arun, Ray Yogiraj, Rajvansh Kruti, Purohit Hemang M, Shah Nehal M, Madharia Arun, Dube Simmi, Shrivastava Neha, Kataria Sushila, Shameem Mohammad, Fatima Nazish, Ghosh Saumitra, Hazra Avijit, D Himanshu, Salgar Veeresh B, Algur Santosh, M L Kala Yadhav, M Pavan Kumar, Panda Samiran, Vishnu Vardhana Rao Mendu, Bhargava Balram

Наблюдательное исследованиеСтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

INTRODUCTION

The effects of COVID-19 infection persist beyond the active phase. Comprehensive description and analysis of the post COVID sequelae in various population groups are critical to minimise the long-term morbidity and mortality associated with COVID-19. This analysis was conducted with an objective to estimate the frequency of post COVID sequelae and subsequently, design a framework for holistic management of post COVID morbidities.

METHODS

Follow-up data collected as part of a registry-based observational study in 31 hospitals across India since September 2020-October 2022 were used for analysis. All consenting hospitalised patients with COVID-19 are telephonically followed up for up to 1 year post-discharge, using a prestructured form focused on symptom reporting.

RESULTS

Dyspnoea, fatigue and mental health issues were reported among 18.6%, 10.5% and 9.3% of the 8042 participants at first follow-up of 30-60 days post-discharge, respectively, which reduced to 11.9%, 6.6% and 9%, respectively, at 1-year follow-up in 2192 participants. Patients who died within 90 days post-discharge were significantly older (adjusted OR (aOR): 1.02, 95% CI: 1.01, 1.03), with at least one comorbidity (aOR: 1.76, 95% CI: 1.31, 2.35), and a higher proportion had required intensive care unit admission during the initial hospitalisation due to COVID-19 (aOR: 1.49, 95% CI: 1.08, 2.06) and were discharged at WHO ordinal scale 6-7 (aOR: 49.13 95% CI: 25.43, 94.92). Anti-SARS-CoV-2 vaccination (at least one dose) was protective against such post-discharge mortality (aOR: 0.19, 95% CI: 0.01, 0.03).

CONCLUSION

Hospitalised patients with COVID-19 experience a variety of long-term sequelae after discharge from hospitals which persists although in reduced proportions until 12 months post-discharge. Developing a holistic management framework with engagement of care outreach workers as well as teleconsultation is a way forward in effective management of post COVID morbidities as well as reducing mortality.

Для цитирования: Kumar Gunjan, Bhalla Ashish, Mukherjee Aparna, Turuk Alka, Talukdar Arunansu, Mukherjee Subhasis, Bhardwaj Pankaj, Menon Geetha R, Sahu Damodar, Misra Puspender, Sharma Lokesh Kumar, Mohindra Ritin, S Samita, Suri Vikas, Das Himadri, Sarkar Debasis, Ghosh Soumyadeep, Ghosh Priyanka, Dutta Moumita, Chakraborty Shreetama, Kumar Deepak, Gupta Manoj Kumar, Goel Akhil Dhanesh, Baruah Tridip Dutta, Kannauje Pankaj Kumar, Shukla Arvind Kumar, Khambholja Janakkumar R, Patel Amit, Shah Nitesh, Bhuniya Sourin, Panigrahi Manoj Kumar, Mohapatra Prasanta Raghab, Pathak Ashish, Sharma Ashish, John Mary, Kaur Kiranpreet, Nongpiur Vijay, Pala Star, Shivnitwar Sachin K, Krishna Bobba Rohil, Dulhani Naveen, Gupta Balkishan, Gupta Jigyasa, Bhandari Sudhir, Agrawal Abhishek, Aggarwal H K, Jain Deepak, Shah Arti D, Naik Parshwa, Panchal Manisha, Anderpa Mayank, Kikon Nyanthung, Humtsoe Christina Nzani, Sharma Nikita, Vohra Rajaat, Patnaik Lipilekha, Sahoo Jagdish Prasad, Joshi Rajnish, Kokane Arun, Ray Yogiraj, Rajvansh Kruti, Purohit Hemang M, Shah Nehal M, Madharia Arun, Dube Simmi, Shrivastava Neha, Kataria Sushila, Shameem Mohammad, Fatima Nazish, Ghosh Saumitra, Hazra Avijit, D Himanshu, Salgar Veeresh B, Algur Santosh, M L Kala Yadhav, M Pavan Kumar, Panda Samiran, Vishnu Vardhana Rao Mendu, Bhargava Balram. Post COVID sequelae among COVID-19 survivors: insights from the Indian National Clinical Registry for COVID-19.. BMJ global health. 2023. DOI: 10.1136/bmjgh-2023-012245.

Предметные рубрики MeSH

Humans COVID-19 Aftercare Patient Discharge Registries Survivors

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