Fertility and sterility · 2013
Clinical pregnancy after uterus transplantation.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Erman Akar Munire, Ozkan Omer, Aydinuraz Batu, Dirican Kerem, Cincik Mehmet, Mendilcioglu Inanc, Simsek Mehmet, Gunseren Filiz, Kocak Huseyin, Ciftcioglu Akif, Gecici Omer, Ozkan Ozlenen
Аннотация
OBJECTIVE: To present the first clinical pregnancy after uterus transplantation.
DESIGN: Case study.
SETTING: Tertiary center.
PATIENT(S): A 23-year-old Mayer-Rokitansky-Kuster-Hauser syndrome patient with previous vaginal reconstruction and uterus transplantation.
INTERVENTION(S): Eighteen months after the transplant, the endometrium was prepared for transfer of the thawed embryos.
MAIN OUTCOME MEASURE(S): Implantation of embryo in an allografted human uterus.
RESULT(S): The first ET cycle with one day 3 thawed embryo resulted in a biochemical pregnancy. The second ET cycle resulted in a clinical pregnancy confirmed with transvaginal ultrasound visualization of an intrauterine gestational sac with decidualization.
CONCLUSION(S): We have presented the first clinical pregnancy in a patient with absolute uterine infertility after uterus allotransplantation. Although the real success is the delivery of a healthy near-term baby, this clinical pregnancy is a great step forward and a proof of concept that the implantation phase works.
DESIGN: Case study.
SETTING: Tertiary center.
PATIENT(S): A 23-year-old Mayer-Rokitansky-Kuster-Hauser syndrome patient with previous vaginal reconstruction and uterus transplantation.
INTERVENTION(S): Eighteen months after the transplant, the endometrium was prepared for transfer of the thawed embryos.
MAIN OUTCOME MEASURE(S): Implantation of embryo in an allografted human uterus.
RESULT(S): The first ET cycle with one day 3 thawed embryo resulted in a biochemical pregnancy. The second ET cycle resulted in a clinical pregnancy confirmed with transvaginal ultrasound visualization of an intrauterine gestational sac with decidualization.
CONCLUSION(S): We have presented the first clinical pregnancy in a patient with absolute uterine infertility after uterus allotransplantation. Although the real success is the delivery of a healthy near-term baby, this clinical pregnancy is a great step forward and a proof of concept that the implantation phase works.