A population-based case-control study of anencephalus and spina bifida in a low-risk area.

For the period 1973 to 1977, a total of 536 cases of anencephalus and spina bifida were ascertained in Los Angeles County, California, a low-risk area, and compared with a 2 per cent random sample of all live births in the county. Women with Spanish surnames had an elevated risk for anencephalus and to a lesser extent for spina bifida; Blacks were at lowest risk, especially for spina bifida. The occurrence of a previous fetal death was a strong risk factor for anencephalus but there was no association between socio-economic status and either of the defects. Advanced maternal age was a stronger risk factor for spina bifida than for anencephalus but, as in other studies in low-risk areas, no increased risk was observed among teenage mothers. Paternal age did not show any independent association after controlling for mother's age. Finally, the association of high birth-order with the birth defects was weakened greatly after simultaneous adjustment for age and ethnicity.