Iron-Catalyzed Alkylative Aminosulfonylation of Alkenes and Alkynes via Radical-Anion Relay.

A novel Fe-catalyzed alkylative aminosulfonylation of alkenes and alkynes with alkyl halides and O-Ts activated hydroxylamines by using Na2S2O4 as a reductant and sulfone source has been developed. The metal-electron-shuttle catalysis was discovered to be vital for the highly efficient generation of sulfonyl radicals and anions without requiring organometallic intermediates. This method provides efficient access to sulfonamides from easily available alkenes and Na2S2O4 and features a broad substrate scope.