Parkinsonism: a clinical marker of exposure to neurotoxins.

Parkinson must be viewed as a final common pathway resulting from a variety of neuropathological lesions which interfere with the integrity of the nigrostriatal system or its output. Exposure to a wide variety of neurotoxic compounds, namely, carbon monoxide, carbon disulfide, manganese and MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), are associated with parkinsonism that has a varying neuropathology, which will be discussed.