BMJ open · 2025
Prevalence and risk factors of Mycoplasma genitalium, Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis infections in pregnant women in seven hospitals in N'Djamena, Chad: a cross-sectional study.
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Anouar Mahamat Mustapha, Gomseu Boris Emmanuel Djoumsie, Sharma Nandita, Afreen Sana, Tsephel Tenzin, Hachim Djamal, Daita Ngam, Bechir Ahmat Annour, Mouctar Abdelkerim Mahamat, Hassan Adam Aboubakar, Dahabaye Adam Mahamat, Adawaye Chatté, Lhagadang Foumsou, Kuiate Jules-Roger, Sethi Sunil
Аннотация
OBJECTIVES: Mycoplasma genitalium, Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis are sexually transmitted pathogens that are highly prevalent in developing countries and are strongly associated with pregnancy complications. In Chad, screening for these sexually transmitted infections (STIs) in pregnant women is based solely on patient-reported symptoms, even though these infections are frequently asymptomatic. This study aims to determine the prevalence of M. genitalium, C. trachomatis, N. gonorrhoeae and T. vaginalis infections, as well as their associated risk factors.
METHODS: In this cross-sectional study, we recruited pregnant women attending antenatal clinics at seven hospitals in N'Djamena. Endocervical swabs were collected, and DNA was extracted. Infections were diagnosed using PCR. Risk factors were identified using a structured questionnaire, and associations were assessed using logistic regression.
RESULTS: A total of 525 pregnant women were enrolled, of whom 78.5% resided in urban areas, with a mean age of 25.16±5.54 years. Overall, 23.99% of the study population were diagnosed with at least one STI. The individual prevalence of M. genitalium, N. gonorrhoeae, C. trachomatis and T. vaginalis infections was 13.33%, 5.14%, 0.95% and 4.57%, respectively. Coinfections were low, with M. genitalium-T. vaginalis at 0.95%, M. genitalium-N. gonorrhoeae at 0.38% and other combinations at 0.19% each. Women residing in rural areas had nearly two times the odds of M. genitalium infection compared with urban residents (OR=1.98), indicating a higher risk. Age<25 years (OR=1.76), employment outside the home (OR=1.70), lack of STI awareness (OR=6.74) and no prior history of M. genitalium infection (OR=1.71) were also associated with significantly increased risk.
CONCLUSIONS: This study demonstrates a high prevalence of STIs among pregnant women in Chad, underscoring the need for systematic screening rather than solely relying on syndromic management.
METHODS: In this cross-sectional study, we recruited pregnant women attending antenatal clinics at seven hospitals in N'Djamena. Endocervical swabs were collected, and DNA was extracted. Infections were diagnosed using PCR. Risk factors were identified using a structured questionnaire, and associations were assessed using logistic regression.
RESULTS: A total of 525 pregnant women were enrolled, of whom 78.5% resided in urban areas, with a mean age of 25.16±5.54 years. Overall, 23.99% of the study population were diagnosed with at least one STI. The individual prevalence of M. genitalium, N. gonorrhoeae, C. trachomatis and T. vaginalis infections was 13.33%, 5.14%, 0.95% and 4.57%, respectively. Coinfections were low, with M. genitalium-T. vaginalis at 0.95%, M. genitalium-N. gonorrhoeae at 0.38% and other combinations at 0.19% each. Women residing in rural areas had nearly two times the odds of M. genitalium infection compared with urban residents (OR=1.98), indicating a higher risk. Age<25 years (OR=1.76), employment outside the home (OR=1.70), lack of STI awareness (OR=6.74) and no prior history of M. genitalium infection (OR=1.71) were also associated with significantly increased risk.
CONCLUSIONS: This study demonstrates a high prevalence of STIs among pregnant women in Chad, underscoring the need for systematic screening rather than solely relying on syndromic management.
Предметные рубрики MeSH
HumansFemaleCross-Sectional StudiesAdultPregnancyRisk FactorsPrevalenceGonorrheaMycoplasma genitaliumNeisseria gonorrhoeaeChlamydia InfectionsChlamydia trachomatisTrichomonas vaginalisPregnancy Complications, InfectiousMycoplasma InfectionsYoung AdultChadTrichomonas VaginitisSexually Transmitted Diseases