[Expression of laminin and laminin receptor in gestational trophoblastic tumor and its significance].

OBJECTIVE

This study was conducted to detect the expression of laminin (LN) and laminin receptor (LN-R) in the specimens of hydatidiform mole (HM), invasive mole (IM) and choriocarcinoma(CC), respectively.

METHODS

The immunohistological staining method was used.

RESULTS

It was found that the level of the laminin expression was higher in the specimens of choriocarcinoma at more advanced stage.

CONCLUSION

The results suggest that there may be relations between the invasion and metastasis of choriocacinoma cell and the malignant degree of this disease, chemotherapy has some effect on the expression of LN and LN-R in gestational trophablastic tumor (GTT), and that LN and LN-R may be of potential value in GTT treatment. However, referring whether LN and LN-R could be used as clinical prognosticators, further studies will be needed.