Considerations on combination therapies for disease modification in Parkinson's.

Clinical trials of monotherapies have failed to deliver disease modification for patients living with Parkinson’s disease, suggesting that a broader strategy for therapeutic development may be required. The medical research charity Cure Parkinson’s convened a workshop to discuss key considerations for developing rationally-designed combination therapies to slow progression of the condition. Here, we review combination therapies and share the conclusions of the meeting.