Pediatric blood & cancer · 2026
European Standard Clinical Practice Recommendations for Olfactory Neuroblastoma in Children and Adolescents: An Updated Consensus by the Expert Group.
СтатьяНазвание и аннотация: Перевод в очереди
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Di Carlo Daniela, Fichera Giulia, Dumont Benoit, Pozzo Enrico, Timmermann Beate, Luscan Romain, Moya-Plana Antoine, Synakiewicz Anna, Bien Ewa, Krawczyk Malgorzata A, do Reis Farinha Nuno Jorge, Alaggio Rita, Pourtsidis Apostolos, Fresneau Brice, Reguerre Yves, Ben-Ami Tal, Virgone Calogero, Roganovic Jelena, Godzinski Jan, Brecht Ines, Schneider Dominik T, Ferrari Andrea, Hero Barbara, Venkatramani Rajkumar, Zanoletti Elisabetta, Ferrari Marco, Orbach Daniel, Bisogno Gianni
Аннотация
Pediatric very rare tumors (VRTs) are a highly heterogeneous group of neoplasms defined by an annual incidence of <2 cases per million children under 18 years. Their rarity precludes prospective clinical trials, resulting in limited evidence-based guidelines and largely individualized treatment approaches. Olfactory neuroblastoma (ON) is an exceptionally rare pediatric VRT arising from the olfactory neuroepithelium, typically affecting adults. In children, ON is locally aggressive and may present with regional or distant metastases. Prognosis depends on stage, histology, and multimodal treatment. Owing to the absence of pediatric-specific guidelines, this project aims to develop internationally harmonized consensus recommendations for diagnosis and management.