Association between MMP-9-C1562Tpolymorphism and susceptibility to preeclampsia: a systematic review and meta-analysis.

OBJECTIVES

This meta-analysis aims to explore the association between MMP-9-C1562T polymorphism and susceptibility to preeclampsia (PE).

MATERIAL AND

METHODS

Four English databases were searched to collect relevant records up to April 2024. The pooled odds ratio (OR) was calculated using Stata 15.0.

RESULTS

A total of 10 studies were enrolled in our systematic review. The results showed that genotype CT at MMP-9-C1562T locus increased the risk of PE versus genotype TT (Genotype CT vs TT: OR = 2.32, 95% CI: 1.27-4.24, P = 0.006), but no significant differences were found in other gene models (C vs T: OR = 0.88, 95% CI: 0.71-1.08, P = 0.225; Genotype CC vs TT: OR = 1.51, 95% CI: 0.87-2.61, P = 0.139; Genotype CC + CT vs TT: OR = 1.63, 95% CI: 0.95-2.81, P = 0.079; Genotype CC vs CT + TT: OR = 0.80, 95% CI: 0.63-1.03, P = 0.086). Subgroup analysis by ethnicity showed a statistically significant difference in the heterozygous model in China (Genotype CT vs TT: OR = 2.38, 95% CI: 1.15 -4.91, P = 0.019).

CONCLUSIONS

Association of MMP-9-C1562T polymorphism with susceptibility to PE exists. Specifically, genotype CT increases the risk of PE versus genotype TT, particularly in Caucasian populations.