Report of a case with aplasia cutis congenita, elevated amniotic fluid alpha-fetoprotein, and positive acetylcholinesterase band.

A case report of a pregnant mother with elevated midtrimester maternal serum alpha-fetoprotein, an elevated amniotic fluid alpha-fetoprotein with a positive acetylcholinesterase band, and grossly normal fetal anatomy is presented. A premature female infant was delivered with bilateral symmetrical flank skin lesions consistent with the diagnosis of aplasia cutis congenita.