Emerging menace of multidrug-resistant organisms in urosepsis: Observations from western India.

Urosepsis is a severe complication of urinary tract infections (UTIs) and is increasingly driven by multidrug-resistant (MDR) organisms, posing major therapeutic challenges, particularly in regions with a high UTI burden. This observational study reports 41 microbiologically confirmed urosepsis cases over 1.5 years from Western India, where climatic factors and the prevalence of urolithiasis predispose to complicated UTIs. High resistance rates were noted to fluoroquinolones, cotrimoxazole, and third-generation cephalosporins, while nitrofurantoin showed retained activity in 78.0%. These findings highlight the escalating threat of MDR pathogens in urosepsis and underscore the need for local antimicrobial stewardship and continued surveillance to guide empirical therapy.