Медицинская библиотека · Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2014

Time-dependent comparative evaluation of some important biomarkers of acute cyanide poisoning in rats: an aid in diagnosis.

Bhattacharya Rahul, Singh Poonam, Palit Meehir, Waghmare Chandrakant, Singh Anil Kumar, Gopalan Natarajan, Kumar Deo

Сравнительное исследованиеСтатьяПеревод в очереди

Аннотация

OBJECTIVE

The study focuses on time-dependent comparative evaluation of various biomarkers of acute cyanide poisoning in rats.

METHODS

Blood gas (analyzer), lactate, pyruvate, cyanide, thiocyanate (spectrophotometer) and 2-amino-2-thiazoline-4-carboxylic acid (ATCA; gas chromatography-mass spectrometry) in plasma or urine, and various physiological parameters (polygraph) were measured.

RESULTS

Cyanide poisoning was characterized by elevated lactate, cyanide, thiocyanate and ATCA concentrations in plasma up to 15 min, 4, 16 and 24 h, respectively, while high urinary thiocyanate and ATCA levels were measured between 4 and 24 h.

CONCLUSION

ATCA concentration in plasma and urine was found to be more reliable indicator of cyanide poisoning.

Для цитирования: Bhattacharya Rahul, Singh Poonam, Palit Meehir, Waghmare Chandrakant, Singh Anil Kumar, Gopalan Natarajan, Kumar Deo. Time-dependent comparative evaluation of some important biomarkers of acute cyanide poisoning in rats: an aid in diagnosis.. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2014. DOI: 10.3109/1354750x.2014.902996.

Предметные рубрики MeSH

Animals Biomarkers Cyanides Male Poisoning Rats Rats, Wistar

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