European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
Habitual tea consumption and survival in laryngeal squamous cell carcinoma: a single-center retrospective cohort (2021-2024).
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Yu Tao, Yue WenHui, Zhang ShuJun
Аннотация
PURPOSE: To examine whether habitual tea consumption is associated with survival and early postoperative complications among patients with laryngeal squamous cell carcinoma (LSCC) [1-4].
METHODS: Single-center retrospective cohort (2021-2024). Adults with primary LSCC treated with curative intent were included (N = 108).
EXPOSURE: regular tea (≥ 3 times/week for ≥ 6 months; n = 73) vs. non-regular (n = 35).
PRIMARY ENDPOINTS: overall survival (OS) and recurrence-free survival (RFS) by Kaplan-Meier with log-rank tests; multivariable Cox adjusted for age, sex, T/N category, overall stage, treatment modality, smoking (pack-years), alcohol use, and Charlson Comorbidity Index (CCI). Median follow-up 23.0 months (interquartile range [IQR] 17.1-32.3).
RESULTS: Two-year RFS was higher in regular tea drinkers than in non-regular drinkers (83.8% vs. 45.8%; log-rank p = 0.0043); two-year OS was similar (72.4% vs. 75.4%; p = 0.5651). Early complications were lower among tea drinkers: 30-day infection 6.8% vs. 20.0% (p = 0.0418) and borderline 90-day dysphagia 4.1% vs. 17.1% (p = 0.0556). Findings were directionally consistent in adjusted analyses.
CONCLUSIONS: Habitual tea consumption was associated with higher RFS and fewer early infections after curative-intent therapy for LSCC, whereas OS did not differ. Results indicate association rather than causation and warrant prospective validation.
METHODS: Single-center retrospective cohort (2021-2024). Adults with primary LSCC treated with curative intent were included (N = 108).
EXPOSURE: regular tea (≥ 3 times/week for ≥ 6 months; n = 73) vs. non-regular (n = 35).
PRIMARY ENDPOINTS: overall survival (OS) and recurrence-free survival (RFS) by Kaplan-Meier with log-rank tests; multivariable Cox adjusted for age, sex, T/N category, overall stage, treatment modality, smoking (pack-years), alcohol use, and Charlson Comorbidity Index (CCI). Median follow-up 23.0 months (interquartile range [IQR] 17.1-32.3).
RESULTS: Two-year RFS was higher in regular tea drinkers than in non-regular drinkers (83.8% vs. 45.8%; log-rank p = 0.0043); two-year OS was similar (72.4% vs. 75.4%; p = 0.5651). Early complications were lower among tea drinkers: 30-day infection 6.8% vs. 20.0% (p = 0.0418) and borderline 90-day dysphagia 4.1% vs. 17.1% (p = 0.0556). Findings were directionally consistent in adjusted analyses.
CONCLUSIONS: Habitual tea consumption was associated with higher RFS and fewer early infections after curative-intent therapy for LSCC, whereas OS did not differ. Results indicate association rather than causation and warrant prospective validation.