Archives of neurology · 1994
Distribution of leptomeningeal glioneuronal heterotopia in alobar holoprosencephaly.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Mizuguchi M, Maekawa S, Kamoshita S
Аннотация
OBJECTIVE: To clarify the pathogenetic significance of the topographic distribution of leptomeningeal glioneuronal heterotopia, a common finding in holoprosencephaly.
DESIGN: Gross, histological, and immunohistochemical observations of alobar holoprosencephaly in brain specimens taken at autopsy.
SETTING: Referral center.
MATERIALS: Brains removed at autopsy from five consecutive patients with alobar holoprosencephaly.
MAIN OUTCOME MEASURES: Immunoperoxidase staining for glial fibrillary acidic protein.
RESULTS: In all brains, leptomeningeal glioneuronal heterotopia showed an identical distribution, ranging from the basal prosencephalon to the pons, with the thickest distribution occurring in the basal prosencephalon.
CONCLUSION: The constant localization implicates leptomeningeal glioneuronal heterotopia in severe dysgenesis of midline prosencephalon, the basic pathogenesis of the anomaly.
DESIGN: Gross, histological, and immunohistochemical observations of alobar holoprosencephaly in brain specimens taken at autopsy.
SETTING: Referral center.
MATERIALS: Brains removed at autopsy from five consecutive patients with alobar holoprosencephaly.
MAIN OUTCOME MEASURES: Immunoperoxidase staining for glial fibrillary acidic protein.
RESULTS: In all brains, leptomeningeal glioneuronal heterotopia showed an identical distribution, ranging from the basal prosencephalon to the pons, with the thickest distribution occurring in the basal prosencephalon.
CONCLUSION: The constant localization implicates leptomeningeal glioneuronal heterotopia in severe dysgenesis of midline prosencephalon, the basic pathogenesis of the anomaly.