Redox biology · 2025
Monitoring ferroptosis in vivo: Iron-driven volatile oxidized lipids as breath biomarkers.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Matsuoka Yuta, Katsumata Yoshinori, Chu Po-Sung, Morikawa Rei, Nakamoto Nobuhiro, Iguchi Kohta, Takahashi Ken, Kou Tadayuki, Ito Ryo, Taura Kojiro, Yazumi Shujiro, Terajima Hiroaki, Honjo Gen, Ichihara Genki, Muramoto Yuki, Sato Kazuki, Maeda Rae, Hata Kazuhiro, Toriu Naoya, Yanagita Motoko, Tajima Masaki, Fagarasan Sidonia, Yamada Ken-Ichi, Sugiura Yuki
Аннотация
Ferroptosis, an iron-dependent cell death mechanism characterized by excessive lipid peroxidation, has been implicated in numerous human diseases and organ pathologies. However, current detection methods necessitate invasive tissue sampling to assess lipid peroxidation, making noninvasive detection of ferroptosis in human subjects extremely challenging. In this study, we employed oxidative volatolomics to comprehensively characterize the volatile oxidized lipids (VOLs) produced during ferroptosis. Polyunsaturated fatty acid-derived VOLs were generated via iron-dependent LPO and released extracellularly as ferroptosis progressed. These VOLs were specifically generated during hepatic ferroptosis in mouse models of acetaminophen-induced liver injury and metabolic dysfunction-associated steatohepatitis (MASH) and were also detectable in the exhaled breath of patients with MASH. Specific VOLs released upon iron-dependent LPO are potential markers of ferroptosis in vivo and may facilitate noninvasive monitoring of cellular health in humans.